Gwyn T Williams
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Explore the profile of Gwyn T Williams including associated specialties, affiliations and a list of published articles.
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38
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1310
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Recent Articles
11.
Mourtada-Maarabouni M, Watson D, Munir M, Farzaneh F, Williams G
Curr Cancer Drug Targets
. 2012 Aug;
13(1):80-91.
PMID: 22920440
Targets for cancer therapy are conventionally selected by identification of molecules acting downstream of established tumour suppressors and oncoproteins, such as p53, c-Myc and Ras. However, the forward genetics approach...
12.
Williams G, Farzaneh F
Nat Rev Cancer
. 2012 Jan;
12(2):84-8.
PMID: 22257949
Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous elements in the production of the protein synthesis machinery of the cell. Recently, however, several independent lines of evidence...
13.
Pickard M, Mourtada-Maarabouni M, Williams G
Biochim Biophys Acta
. 2011 May;
1812(9):1146-53.
PMID: 21550398
FAU, which encodes a ubiquitin-like protein (termed FUBI) with ribosomal protein S30 as a carboxy-terminal extension, has recently been identified as a pro-apoptotic regulatory gene. This activity may be mediated...
14.
Williams G, Mourtada-Maarabouni M, Farzaneh F
Biochem Soc Trans
. 2011 Mar;
39(2):482-6.
PMID: 21428924
Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5'-TOP (5'-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway....
15.
Pickard M, Edwards S, Cooper C, Williams G
Prostate
. 2010 Aug;
70(14):1513-23.
PMID: 20687224
Background: The molecular control of cell death through apoptosis is compromised in prostate cancer cells, resulting in inappropriate cell survival and resistance to cytotoxic therapy. Reduced expression of the functionally...
16.
Hasan A, Mourtada-Maarabouni M, Hameed M, Williams G, Dent G
Int Immunopharmacol
. 2010 Aug;
10(9):1017-21.
PMID: 20685403
Background: Eosinophils are characteristic participants in allergic inflammation. The intracellular signalling mechanisms involved in the migration of eosinophils to sites of allergic inflammation are poorly understood. Chemotactic responses of eosinophils...
17.
Mourtada-Maarabouni M, Hasan A, Farzaneh F, Williams G
Mol Pharmacol
. 2010 Apr;
78(1):19-28.
PMID: 20421347
The central importance of the serine/threonine protein kinase mTOR (mammalian Target of Rapamycin) in the control of cell growth and proliferation is well established. However, our knowledge both of the...
18.
Moss E, Mourtada-Maarabouni M, Pickard M, Redman C, Williams G
Genes Chromosomes Cancer
. 2009 Oct;
49(1):70-7.
PMID: 19830698
The development of chemotherapy resistance by cancer cells is complex, using different mechanisms and pathways. The gene FAU (Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV)-associated ubiquitously expressed gene) was identified through functional...
19.
Pickard M, Green A, Ellis I, Caldas C, Hedge V, Mourtada-Maarabouni M, et al.
Breast Cancer Res
. 2009 Aug;
11(4):R60.
PMID: 19671159
Introduction: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development...
20.
Mourtada-Maarabouni M, Williams G
Leuk Res
. 2009 Jun;
33(11):1539-51.
PMID: 19539371
The control of T-cell survival is of overwhelming importance for preventing leukemia and lymphoma. The present report demonstrates that the serine/threonine protein phosphatase PP4 regulates the survival of both leukemic...