Guoqiang Dong
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Explore the profile of Guoqiang Dong including associated specialties, affiliations and a list of published articles.
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135
Citations
1459
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Recent Articles
1.
Deng F, Wen X, Dong G, Wang X, He H, Zhu R, et al.
Front Public Health
. 2025 Jan;
12():1499349.
PMID: 39872106
Background: Environmental health literacy (EHL) aims to enable individuals to make informed choices to reduce health risks and protect the environment. Objectives: To assess the EHL of residents in Shaanxi...
2.
Zhang M, Yang W, Liu N, Tu J, Lin J, Dong G, et al.
J Med Chem
. 2025 Jan;
68(2):1668-1681.
PMID: 39754582
Invasive candidiasis has attracted global attention with a high incidence and mortality. Current antifungal drugs are limited by unfavorable therapeutic efficacy, significant hepatorenal toxicity, and the development of drug resistance....
3.
Ma J, Zhang Y, Gu S, Ge C, Mae S, Young A, et al.
Lancet Digit Health
. 2024 Oct;
6(11):e815-e826.
PMID: 39455194
Deep learning has shown great potential to automate abdominal organ segmentation and quantification. However, most existing algorithms rely on expert annotations and do not have comprehensive evaluations in real-world multinational...
4.
Cheng J, Dong G, Wang W, Sheng C
Chembiochem
. 2024 Oct;
26(1):e202400682.
PMID: 39367518
Proteolysis-targeting chimera (PROTAC) has emerged as an attractive therapeutic modality in drug discovery. PROTACs are bifunctional molecules that effectively bridge proteins of interest (POIs) with E3 ubiquitin ligases, such that,...
5.
Chen S, Wang W, Chen Z, Li R, Wu Z, Dong G, et al.
J Med Chem
. 2024 Aug;
67(17):15807-15815.
PMID: 39146536
Targeted protein degradation through the lysosomal pathway has attracted increasing attention and expanded the scope of degradable proteins. However, the endogenous lysosomal degradation strategies are mainly based on antibodies or...
6.
Zhang X, Wang W, Dong G, Song Y, Zhai X, Sheng C
Bioorg Med Chem Lett
. 2024 Jun;
109:129838.
PMID: 38838918
Aberrant activation of the JAK-STAT pathway is evident in various human diseases including cancers. Proteolysis targeting chimeras (PROTACs) provide an attractive strategy for developing novel JAK-targeting drugs. Herein, a series...
7.
Lin L, Zhu R, Li W, Dong G, You H
Micromachines (Basel)
. 2024 Apr;
15(4).
PMID: 38675233
The precise isolation of circulating tumor cells (CTCs) from blood samples is a potent tool for cancer diagnosis and clinical prognosis. However, CTCs are present in extremely low quantities in...
8.
Wu Z, Chen S, Chen Z, Dong G, Xu D, Sheng C
J Med Chem
. 2024 Apr;
67(9):7373-7384.
PMID: 38646851
Natural product evodiamine is a multitargeting antitumor lead compound. However, clinical development of evodiamine derivatives was hampered by poor water solubility and limited antitumor potency. Herein, a series of evodiamine-glucose...
9.
Drugtamer-PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy
He S, Fang Y, Zhu Y, Ma Z, Dong G, Sheng C
Adv Sci (Weinh)
. 2024 Apr;
11(25):e2401623.
PMID: 38639391
Proteolysis-targeting chimeras (PROTACs) have emerged as a promising strategy for targeted protein degradation and drug discovery. To overcome the inherent limitations of conventional PROTACs, an innovative drugtamer-PROTAC conjugation approach is...
10.
Yang S, Sun D, Wu Y, Chen S, Guo Y, Li J, et al.
J Med Chem
. 2024 Feb;
67(5):4120-4130.
PMID: 38367219
Nicotinamide adenine dinucleotide (NAD) plays a crucial role in the cellular energy metabolism pathway. Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme involved in the biosynthesis of NAD. Herein, a series...