Guizhu Hong
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Explore the profile of Guizhu Hong including associated specialties, affiliations and a list of published articles.
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15
Citations
586
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Recent Articles
1.
Lai W, He Y, Zhou B, Wu Q, Wu H, Chen J, et al.
Phytomedicine
. 2024 Nov;
135:156208.
PMID: 39550919
Background: Ischemic stroke is a common cerebrovascular disease characterized by high incidence, disability, mortality, and recurrence. The limitations of current pharmacological treatments, which have primarily single neuroprotective action and a...
2.
Lai W, Huang S, Liu J, Zhou B, Yu Z, Brown J, et al.
FASEB J
. 2024 Jun;
38(13):e23781.
PMID: 38941212
Reactive astrocytes are important pathophysiologically and synthesize neurosteroids. We observed that LPS increased immunoreactive TLR4 and key steroidogenic enzymes in cortical astrocytes of rats and investigated whether corticosteroids are produced...
3.
Lai W, Luo R, Tang Y, Yu Z, Zhou B, Yang Z, et al.
Phytother Res
. 2024 Mar;
38(6):2619-2640.
PMID: 38488455
Salidroside, a principal bioactive component of Rhodiola crenulata, is neuroprotective across a wide time window in stroke models. We investigated whether salidroside induced neurogenesis after cerebral ischemia and aimed to...
4.
Yang Z, Huang X, Lai W, Tang Y, Liu J, Wang Y, et al.
Eur J Med Chem
. 2020 Oct;
209:112935.
PMID: 33097301
Salidroside [(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenethoxy)tetrahy-dro-2H-pyran-3,4,5-triol] is an antioxidant, anti-inflammatory and neuroprotective agent, but its drug-like properties are unoptimized and its mechanism of actions is uncertain. We synthesized twenty-six novel derivatives of salidroside and...
5.
Lai W, Xie X, Zhang X, Wang Y, Chu K, Brown J, et al.
Inflammation
. 2017 Dec;
41(2):449-463.
PMID: 29198014
Salidroside is neuroprotective across a wide therapeutic time-window after cerebral ischemia-reperfusion injury (IRI). Here, we investigated the role of complement in mediating effects of salidroside after cerebral IRI in rats....
6.
Wei Y, Hong H, Zhang X, Lai W, Wang Y, Chu K, et al.
Inflammation
. 2017 May;
40(4):1297-1309.
PMID: 28478514
Salidroside is being investigated for its therapeutic potential in stroke because it is neuroprotective over an extended therapeutic window of time. In the present study, we investigated the mechanisms underlying...
7.
Lai W, Zheng Z, Zhang X, Wei Y, Chu K, Brown J, et al.
Neurotox Res
. 2015 Apr;
28(2):108-21.
PMID: 25911293
Salidroside exhibits anti-inflammatory, anti-oxidative, and anti-apoptotic properties. To identify whether salidroside might be a candidate for treating ischemic stroke, we investigated the effects of salidroside or vehicle, given daily for...
8.
Lai W, Tian X, Xiang Q, Chu K, Wei Y, Deng J, et al.
Mol Endocrinol
. 2015 Mar;
29(4):558-70.
PMID: 25734515
Inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) represents a therapeutic target for treating hyperglycemia in type 2 diabetes. Here, we investigate the effects of 11β-HSD1 on the innate immune response...
9.
Spraggs C, McCarthy A, McCarthy L, Hong G, Hughes A, Lin X, et al.
Pharmacogenet Genomics
. 2007 Nov;
17(12):1065-76.
PMID: 18004211
Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists are highly effective in the treatment of type 2 diabetes. In some patients, PPARgamma ligands are associated with fluid retention/oedema, for which the mechanism...
10.
Rahmoune H, Thompson P, Ward J, Smith C, Hong G, Brown J
Diabetes
. 2005 Nov;
54(12):3427-34.
PMID: 16306358
The bulk of glucose that is filtered by the renal glomerulus is reabsorbed by the glucose transporters of the proximal convoluted tubular epithelium. However, it has been difficult to investigate...