Gregory R Mundy
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Explore the profile of Gregory R Mundy including associated specialties, affiliations and a list of published articles.
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68
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5216
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Recent Articles
1.
Zhao M, Ko S, Garrett I, Mundy G, Gutierrez G, Edwards J
Br J Pharmacol
. 2018 Aug;
175(21):4183-4192.
PMID: 30125963
Background And Purpose: The polyphenol resveratrol (RSV) exists in high quantities in certain foods (e.g. grapes and nuts). However, the capacity of RSV to confer physiological health benefits and a...
2.
Yang W, Guo D, Harris M, Cui Y, Gluhak-Heinrich J, Wu J, et al.
J Cell Sci
. 2013 Jul;
126(Pt 18):4085-98.
PMID: 23843612
We generated a new Bmp2 conditional-knockout allele without a neo cassette that removes the Bmp2 gene from osteoblasts (Bmp2-cKO(ob)) using the 3.6Col1a1-Cre transgenic model. Bones of Bmp2-cKO(ob) mice are thinner,...
3.
Zhuang J, Zhang J, Lwin S, Edwards J, Edwards C, Mundy G, et al.
PLoS One
. 2012 Nov;
7(11):e48871.
PMID: 23173040
Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The number and activity of osteoclasts are often enhanced by tumors. However, the origin of osteoclasts is unknown....
4.
Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling
Edwards J, Perrien D, Fleming N, Nyman J, Ono K, Connelly L, et al.
J Bone Miner Res
. 2012 Nov;
28(4):960-9.
PMID: 23172686
Silent information regulator T1 (SirT1) is linked to longevity and negatively controls NF-κB signaling, a crucial mediator of survival and regulator of both osteoclasts and osteoblasts. Here we show that...
5.
Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y, et al.
Cancer Res
. 2012 Jun;
72(16):4238-49.
PMID: 22738911
The continuous release of bone-stored growth factors after bone resorption promotes the colonization of circulating cancer cells. However, the precise role of each of the various growth factors remains unclear....
6.
Fowler J, Mundy G, Lwin S, Edwards C
Cancer Res
. 2012 Mar;
72(9):2183-9.
PMID: 22374979
The rapid progression of multiple myeloma is dependent upon cellular interactions within the bone marrow microenvironment. In vitro studies suggest that bone marrow stromal cells (BMSC) can promote myeloma growth...
7.
Biswas S, Nyman J, Alvarez J, Chakrabarti A, Ayres A, Sterling J, et al.
PLoS One
. 2011 Nov;
6(11):e27090.
PMID: 22096521
Breast cancer often metastasizes to bone causing osteolytic bone resorption which releases active TGFβ. Because TGFβ favors progression of breast cancer metastasis to bone, we hypothesized that treatment using anti-TGFβ...
8.
Fowler J, Lwin S, Drake M, Edwards J, Kyle R, Mundy G, et al.
Blood
. 2011 Sep;
118(22):5872-82.
PMID: 21908434
The contributions of the host microenvironment to the pathogenesis of multiple myeloma, including progression from the non-malignant disorder monoclonal gammopathy of undetermined significance, are poorly understood. In the present study,...
9.
Johnson R, Merkel A, Danilin S, Nguyen M, Mundy G, Sterling J
Anticancer Res
. 2011 Aug;
31(9):2705-12.
PMID: 21868511
Background: Breast cancer cells frequently metastasize to bone, where they up-regulate their expression of the transcription factor GLI2 and the downstream osteolytic factor parathyroid hormone-related protein (PTHrP). The guanosine nucleotide...
10.
Nyman J, Lynch C, Perrien D, Thiolloy S, OQuinn E, Patil C, et al.
J Bone Miner Res
. 2011 May;
26(6):1252-60.
PMID: 21611966
Matrix metalloproteinases (MMPs) are capable of processing certain components of bone tissue, including type 1 collagen, a determinant of the biomechanical properties of bone tissue, and they are expressed by...