Birgit T Priest
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Explore the profile of Birgit T Priest including associated specialties, affiliations and a list of published articles.
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56
Citations
1000
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Recent Articles
1.
Diaz N, Perez C, Escribano A, Sanz G, Priego J, Lafuente C, et al.
Nature
. 2024 May;
629(8013):945-950.
PMID: 38720069
Lipoprotein(a) (Lp(a)), an independent, causal cardiovascular risk factor, is a lipoprotein particle that is formed by the interaction of a low-density lipoprotein (LDL) particle and apolipoprotein(a) (apo(a)). Apo(a) first binds...
2.
Wilenkin B, Burris K, Eastwood B, Sher E, Williams A, Priest B
Assay Drug Dev Technol
. 2019 Oct;
17(7):310-321.
PMID: 31634018
in vivo
3.
Priest B, Pasternak A
Future Med Chem
. 2017 Oct;
9(16):1963-1977.
PMID: 29076349
K1.1 (renal outer medullary K) channels are potassium channels expressed almost exclusively in the kidney and play a role in the body's electrolyte and water balance. Potassium efflux through K1.1...
4.
Zhang X, Priest B, Belfer I, Gold M
Elife
. 2017 May;
6.
PMID: 28508747
Available evidence indicates voltage-gated Na channels (VGSCs) in peripheral sensory neurons are essential for the pain and hypersensitivity associated with tissue injury. However, our understanding of the biophysical and pharmacological...
5.
Dong S, VanGelder K, Shi Z, Yu Y, Wu Z, Ferguson R, et al.
Bioorg Med Chem Lett
. 2017 Apr;
27(11):2559-2566.
PMID: 28431879
SAR in the previously described spirocyclic ROMK inhibitor series was further evolved from lead 4 by modification of the spirocyclic core and identification of novel right-side pharmacophores. In this process,...
6.
Guo L, Parker D, Zang Y, Sweis R, Liu W, Sherer E, et al.
ACS Med Chem Lett
. 2016 Dec;
7(12):1107-1111.
PMID: 27994747
GPR142 has been identified as a potential glucose-stimulated insulin secretion (GSIS) target for the treatment of type 2 diabetes mellitus (T2DM). A class of triazole GPR142 agonists was discovered through...
7.
Zhu Y, de Jesus R, Tang H, Walsh S, Jiang J, Gu X, et al.
Bioorg Med Chem Lett
. 2016 Nov;
26(23):5695-5702.
PMID: 27839686
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors...
8.
Tang H, Zhu Y, Teumelsan N, Walsh S, Shahripour A, Priest B, et al.
ACS Med Chem Lett
. 2016 Jul;
7(7):697-701.
PMID: 27437080
ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney...
9.
Hampton C, Zhou X, Priest B, Pai L, Felix J, Thomas-Fowlkes B, et al.
J Pharmacol Exp Ther
. 2016 Jul;
359(1):194-206.
PMID: 27432892
The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption...
10.
Walsh S, Shahripour A, Tang H, de Jesus R, Teumelsan N, Zhu Y, et al.
Bioorg Med Chem Lett
. 2016 Mar;
26(9):2339-43.
PMID: 27017115
Following the discovery of small molecule acyl piperazine ROMK inhibitors and their initial preclinical validation as a novel diuretic agent, our group set out to discover new ROMK inhibitors with...