Gregory I Vladimer
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Explore the profile of Gregory I Vladimer including associated specialties, affiliations and a list of published articles.
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24
Citations
2121
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Recent Articles
11.
Kandasamy R, Vladimer G, Snijder B, Muller A, Rebsamen M, Bigenzahn J, et al.
NPJ Syst Biol Appl
. 2017 Jul;
2:16027.
PMID: 28725479
Studying the relationship between virus infection and cellular response is paradigmatic for our understanding of how perturbation changes biological systems. Immune response, in this context is a complex yet evolutionarily...
12.
Vladimer G, Snijder B, Krall N, Bigenzahn J, Huber K, Lardeau C, et al.
Nat Chem Biol
. 2017 Apr;
13(6):681-690.
PMID: 28437395
Small-molecule drugs may complement antibody-based therapies in an immune-oncology setting, yet systematic methods for the identification and characterization of the immunomodulatory properties of these entities are lacking. We surveyed the...
13.
Bigenzahn J, Fauster A, Rebsamen M, Kandasamy R, Scorzoni S, Vladimer G, et al.
Mol Cell Proteomics
. 2016 Mar;
15(3):1139-50.
PMID: 26933192
Tandem affinity purification-mass spectrometry (TAP-MS) is a popular strategy for the identification of protein-protein interactions, characterization of protein complexes, and entire networks. Its employment in cellular settings best fitting the...
14.
Marty-Roix R, Vladimer G, Pouliot K, Weng D, Buglione-Corbett R, West K, et al.
J Biol Chem
. 2015 Nov;
291(3):1123-36.
PMID: 26555265
Many immunostimulants act as vaccine adjuvants via activation of the innate immune system, although in many cases it is unclear which specific molecules contribute to the stimulatory activity. QS-21 is...
15.
Koberlin M, Snijder B, Heinz L, Baumann C, Fauster A, Vladimer G, et al.
Cell
. 2015 Jun;
162(1):170-83.
PMID: 26095250
Lipid composition affects the biophysical properties of membranes that provide a platform for receptor-mediated cellular signaling. To study the regulatory role of membrane lipid composition, we combined genetic perturbations of...
16.
Herdy B, Karonitsch T, Vladimer G, Tan C, Stukalov A, Trefzer C, et al.
Eur J Immunol
. 2015 Feb;
45(5):1500-11.
PMID: 25678110
Secretion of type I interferon (IFN) is the first cellular reaction to invading pathogens. Despite the protective function of these cytokines, an excessive response to their action can contribute to...
17.
Nilsen N, Vladimer G, Stenvik J, Orning M, Zeid-Kilani M, Bugge M, et al.
J Biol Chem
. 2014 Dec;
290(6):3209-22.
PMID: 25505250
Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the Toll/interleukin-1 receptor adaptors...
18.
Willmann K, Klaver S, Dogu F, Santos-Valente E, Garncarz W, Bilic I, et al.
Nat Commun
. 2014 Nov;
5:5360.
PMID: 25406581
Primary immunodeficiency disorders enable identification of genes with crucial roles in the human immune system. Here we study patients suffering from recurrent bacterial, viral and Cryptosporidium infections, and identify a...
19.
Schmidt-Lauber C, Bossaller L, Abujudeh H, Vladimer G, Christ A, Fitzgerald K, et al.
Ann Rheum Dis
. 2014 Jun;
74(11):2062-9.
PMID: 24914072
Objective: Nephrogenic systemic fibrosis (NSF) is a progressive fibrosing disorder that may develop in patients with chronic kidney disease after administration of gadolinium (Gd)-based contrast agents (GBCAs). In the setting...
20.
Weng D, Marty-Roix R, Ganesan S, Proulx M, Vladimer G, Kaiser W, et al.
Proc Natl Acad Sci U S A
. 2014 May;
111(20):7391-6.
PMID: 24799678
A number of pathogens cause host cell death upon infection, and Yersinia pestis, infamous for its role in large pandemics such as the "Black Death" in medieval Europe, induces considerable...