Gregg S Jones
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Explore the profile of Gregg S Jones including associated specialties, affiliations and a list of published articles.
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12
Citations
561
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Recent Articles
1.
Bam R, Hansen D, Irrinki A, Mulato A, Jones G, Hesselgesser J, et al.
Antimicrob Agents Chemother
. 2016 Nov;
61(1).
PMID: 27799218
GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic...
2.
Tsiang M, Jones G, Goldsmith J, Mulato A, Hansen D, Kan E, et al.
Antimicrob Agents Chemother
. 2016 Sep;
60(12):7086-7097.
PMID: 27645238
Bictegravir (BIC; GS-9883), a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase (IN), specifically targets IN strand transfer activity (50% inhibitory concentration [IC] of 7.5 ± 0.3 nM) and HIV-1...
3.
Del Prete G, Smedley J, MacAllister R, Jones G, Li B, Hattersley J, et al.
AIDS Res Hum Retroviruses
. 2015 Jul;
32(2):163-8.
PMID: 26150024
The use of nonhuman primate (NHP) models to study persistent residual virus and viral eradication strategies in combination antiretroviral therapy (cART)-treated individuals requires regimens that effectively suppress SIV replication to...
4.
Leon B, Navarro G, Dickey B, Stepan G, Tsai A, Jones G, et al.
Org Lett
. 2015 Jan;
17(2):262-5.
PMID: 25560385
Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV...
5.
Mejia E, Loveridge S, Stepan G, Tsai A, Jones G, Barnes T, et al.
J Nat Prod
. 2014 Feb;
77(3):618-24.
PMID: 24495105
An extract of Humicola fuscoatra (UCSC strain no. 108111A) was shown to reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells. We report the...
6.
Tsiang M, Jones G, Niedziela-Majka A, Kan E, Lansdon E, Huang W, et al.
J Biol Chem
. 2012 Apr;
287(25):21189-203.
PMID: 22535962
tert-Butoxy-(4-phenyl-quinolin-3-yl)-acetic acids (tBPQA) are a new class of HIV-1 integrase (IN) inhibitors that are structurally distinct from IN strand transfer inhibitors but analogous to LEDGINs. LEDGINs are a class of...
7.
Margot N, Hluhanich R, Jones G, Andreatta K, Tsiang M, McColl D, et al.
Antiviral Res
. 2011 Dec;
93(2):288-296.
PMID: 22197635
Elvitegravir is a strand transfer inhibitor of HIV-1 integrase that is currently undergoing phase 3 clinical testing. The two predominant metabolites of elvitegravir, M1 and M4 (elvitegravir hydroxide and elvitegravir...
8.
Tsiang M, Jones G, Hung M, Samuel D, Novikov N, Mukund S, et al.
Biochemistry
. 2011 Jan;
50(10):1567-81.
PMID: 21222490
We have developed a homogeneous time-resolved fluorescence resonance energy transfer (FRET)-based assay that detects the formation of HIV-1 integrase (IN) dimers. The assay utilizes IN monomers that express two different...
9.
Tsiang M, Jones G, Hung M, Mukund S, Han B, Liu X, et al.
J Biol Chem
. 2009 Oct;
284(48):33580-99.
PMID: 19801648
The interaction between lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF) and human immunodeficiency virus type 1 (HIV-1) integrase (IN) is essential for HIV-1 replication. Homogeneous time-resolved fluorescence resonance energy transfer...
10.
Jones G, Yu F, Zeynalzadegan A, Hesselgesser J, Chen X, Chen J, et al.
Antimicrob Agents Chemother
. 2008 Dec;
53(3):1194-203.
PMID: 19104010
GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of...