Graham J Britton
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Explore the profile of Graham J Britton including associated specialties, affiliations and a list of published articles.
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29
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2202
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Recent Articles
1.
Gutzeit C, Grasset E, Matthews D, Maglione P, Britton G, Miller H, et al.
Sci Adv
. 2025 Feb;
11(7):eado9455.
PMID: 39937896
The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG...
2.
Britton G, Mogno I, Chen-Liaw A, Plitt T, Helmus D, Bongers G, et al.
bioRxiv
. 2025 Jan;
PMID: 39868147
We examine disease-specific and cross-disease functions of the human gut microbiome by colonizing germ-free mice, at risk for inflammatory arthritis, colitis, or neuroinflammation, with over 100 human fecal microbiomes from...
3.
Shang J, Del Valle D, Britton G, Mead K, Rajpal U, Chen-Liaw A, et al.
J Exp Med
. 2024 Dec;
222(1.
PMID: 39666007
Immunotherapy-related colitis (irC) frequently emerges as an immune-related adverse event during immune checkpoint inhibitor therapy and is presumably influenced by the gut microbiota. We longitudinally studied microbiomes from 38 ICI-treated...
4.
Thompson K, Bonham K, Ilott N, Britton G, Colmenero P, Bullers S, et al.
Sci Transl Med
. 2023 Jul;
15(706):eabn4722.
PMID: 37494472
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has been implicated in inflammatory conditions, but large-scale metagenomic evaluations have not yet traced the routes by which...
5.
Spindler M, Mogno I, Suri P, Britton G, Faith J
Proc Natl Acad Sci U S A
. 2023 Mar;
120(12):e2215914120.
PMID: 36917674
How bacterial strains within a complex human microbiota collectively shape intestinal T cell homeostasis is not well understood. Methods that quickly identify effector strains or species that drive specific mucosal...
6.
Bianchimano P, Britton G, Wallach D, Smith E, Cox L, Liu S, et al.
Microbiome
. 2022 Oct;
10(1):174.
PMID: 36253847
Background: The gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune encephalomyelitis (EAE). Prior studies have demonstrated that the multiple sclerosis...
7.
Spindler M, Siu S, Mogno I, Li Z, Yang C, Mehandru S, et al.
Cell Host Microbe
. 2022 Sep;
30(10):1481-1498.e5.
PMID: 36099923
The potential of commensal bacteria to modulate host immunity remains largely uncharacterized, largely due to the vast number of strains that comprise the human gut microbiota. We have developed a...
8.
Aggarwala V, Mogno I, Li Z, Yang C, Britton G, Chen-Liaw A, et al.
Nat Microbiol
. 2022 Apr;
7(5):736.
PMID: 35388189
No abstract available.
9.
Aggarwala V, Mogno I, Li Z, Yang C, Britton G, Chen-Liaw A, et al.
Nat Microbiol
. 2021 Sep;
6(10):1309-1318.
PMID: 34580445
Fecal microbiota transplantation (FMT) has been successfully applied to treat recurrent Clostridium difficile infection in humans, but a precise method to measure which bacterial strains stably engraft in recipients and...
10.
Britton G, Faith J
Annu Rev Microbiol
. 2021 Aug;
75:223-242.
PMID: 34348027
Despite identification of numerous associations between microbiomes and diseases, the complexity of the human microbiome has hindered identification of individual species and strains that are causative in host phenotype or...