Gordon C Weir
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Explore the profile of Gordon C Weir including associated specialties, affiliations and a list of published articles.
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126
Citations
5864
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Recent Articles
1.
French A, Hollister-Lock J, Sullivan B, Stas E, Hwa A, Weir G, et al.
Cell Transplant
. 2024 Oct;
33:9636897241283728.
PMID: 39361612
Human islets can be transplanted into the portal vein for T1 diabetes, and a similar procedure is being used in a clinical trial for stem cell-derived beta-like cells. Efforts have...
2.
Weir G, Bonner-Weir S
Diabetes
. 2023 Nov;
72(12):1741-1747.
PMID: 37983524
In type 1 diabetes, the reduced glucagon response to insulin-induced hypoglycemia has been used to argue that β-cell secretion of insulin is required for the full glucagon counterregulatory response. For...
3.
Weir G, Bonner-Weir S
Front Endocrinol (Lausanne)
. 2023 Jul;
14:1213954.
PMID: 37409234
As diabetes continues to grow as major health problem, there has been great progress in understanding the important role of pancreatic beta-cells in its pathogenesis. Diabetes develops when the normal...
4.
Doloff J, Ma M, Sadraei A, Tam H, Farah S, Hollister-Lock J, et al.
Sci Adv
. 2023 Jun;
9(24):eade9488.
PMID: 37327334
Biomedical devices comprise a major component of modern medicine, however immune-mediated fibrosis and rejection can limit their function over time. Here, we describe a humanized mouse model that recapitulates fibrosis...
5.
6.
Weir G, Butler P, Bonner-Weir S
Metabolism
. 2021 Sep;
124:154870.
PMID: 34480921
β cells in the hyperglycemic environment of diabetes have marked changes in phenotype and function that are largely reversible if glucose levels can be returned to normal. A leading hypothesis...
7.
Weir G, Bonner-Weir S
J Clin Invest
. 2021 Jun;
131(12).
PMID: 34128470
During progression to both types 1 and 2 diabetes (T1D, T2D), there is a striking loss of glucose-induced first-phase insulin release (FPIR), which is known to predict the onset of...
8.
9.
Weir G, Gaglia J, Bonner-Weir S
Lancet Diabetes Endocrinol
. 2020 Apr;
8(5):370-371.
PMID: 32333872
No abstract available.
10.
Ebrahimi A, Hollister-Lock J, Sullivan B, Tsuchida R, Bonner-Weir S, Weir G
Mol Metab
. 2020 Apr;
35:100959.
PMID: 32244186
Objective: As diabetes develops, marked reductions of insulin secretion are associated with very modest elevations of glucose. We wondered if these glucose changes disrupt beta cell differentiation enough to account...