Gopalakrishnan Aridoss
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Explore the profile of Gopalakrishnan Aridoss including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Puppala M, Zhao X, Casemore D, Zhou B, Aridoss G, Narayanapillai S, et al.
Bioorg Med Chem
. 2016 Feb;
24(6):1292-7.
PMID: 26867486
4H-Chromene-based compounds, for example, CXL017, CXL035, and CXL055, have a unique anticancer potential that they selectively kill multi-drug resistant cancer cells. Reported herein is the extended structure-activity relationship (SAR) study,...
2.
Aridoss G, Zhou B, Hermanson D, Bleeker N, Xing C
J Med Chem
. 2012 May;
55(11):5566-81.
PMID: 22582991
Multidrug resistance (MDR) against standard therapies poses a serious challenge in cancer treatment, and there is a clinical need for new anticancer agents that would selectively target MDR malignancies. Our...
3.
Aridoss G, Zhao C, Borosky G, Laali K
J Org Chem
. 2012 Apr;
77(8):4152-5.
PMID: 22480162
A series of 1-aryl/alkyl-1H-1,2,3,4-tetrazoles, 5-substituted 1H-tetrazoles, and 1,5- and 2,5-disubstituted 1H-tetrazoles were studied by a combination of experimental NMR (natural abundance (15)N, (15)N/(1)H HMBC, and (13)C) and computational GIAO-NMR techniques...
4.
Aridoss G, Laali K
J Org Chem
. 2011 Aug;
76(19):8088-94.
PMID: 21861464
Acting as in situ sources of triflyl nitrate (TfONO(2)) and trifluoroacetyl nitrate (CF(3)COONO(2)), the EAN/Tf(2)O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid...
5.
Aridoss G, Sarca V, Ponder Jr J, Crowe J, Laali K
Org Biomol Chem
. 2011 Feb;
9(7):2518-29.
PMID: 21336396
Metallic triflates M(OTf)(3) (M = Bi, Sc, Yb), immobilized in imidazolium ionic liquids [BMIM][BF(4)], [BMIM][PF(6)] and [BMIM][OTf] are efficient systems for one-pot reactions of propargylic alcohols 1,3-diphenyl-2-propyn-1-ol Ia, 1-methyl-3-phenyl-2-propyn-1-ol Ib,...
6.
Aridoss G, Amirthaganesan S, Jeong Y
Bioorg Med Chem Lett
. 2010 Mar;
20(7):2242-9.
PMID: 20207140
In an effort to expand the spectrum of antibacterial activity associated with piperidin-4-one derivatives, we have synthesized two series of 3-carboxyethyl-2,6-diphenyl-4-hydroxy-Delta(3)-tetrahydropyridine derivatives bearing diversified heterocyclic and aromatic systems at the...
7.
Parthiban P, Aridoss G, Rathika P, Ramkumar V, Kabilan S
Bioorg Med Chem Lett
. 2009 Nov;
19(24):6981-5.
PMID: 19879756
Two series of bicyclic oxime ethers viz, 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one O-benzyloximes 13-24 and 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-one O-benzyloximes 31-36 were synthesized and stereochemistry was established by their spectral (1D and 2D NMR) and crystal studies....
8.
Parthiban P, Aridoss G, Rathika P, Ramkumar V, Kabilan S
Bioorg Med Chem Lett
. 2009 May;
19(11):2981-5.
PMID: 19419867
Three series of oxime ethers viz, 2,6-diarylpiperidin-4-one O-benzyloximes 5a-o, 2,6-diaryltetrahydropyran-4-one O-benzyloximes 7a-e and 2,6-diaryltetrahydrothiopyran-4-one O-benzyloximes 11a-b and 12a-c were synthesized and stereochemistry is established by their spectral and single crystal...
9.
Aridoss G, Amirthaganesan S, Ashok Kumar N, Kim J, Lim K, Kabilan S, et al.
Bioorg Med Chem Lett
. 2008 Oct;
18(24):6542-8.
PMID: 18952418
The raise in clinical significance of multidrug-resistant bacterial pathogens has directed us to synthesize 2,6-diarylpiperidin-4-one and Delta(3)-tetrahydropyridin-4-ol based benzimidazole and O-arylsulfonyl derivatives. X-ray crystal structure of tetrahydropyridinol (23) confirmed a...
10.
Parthiban P, Ramachandran R, Aridoss G, Kabilan S
Magn Reson Chem
. 2008 May;
46(8):780-5.
PMID: 18509862
The (1)H and (13)C NMR spectra of 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-ones (1-2), oximes (3-8) and O-benzyl oximes (9-12) were recorded. The chemical shifts were unambiguously assigned using 1D and 2D NMR spectral data....