Gopal Thinakaran
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Explore the profile of Gopal Thinakaran including associated specialties, affiliations and a list of published articles.
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76
Citations
4025
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Recent Articles
1.
Zhao X, Li Y, Zhang S, Sudwarts A, Zhang H, Kozlova A, et al.
medRxiv
. 2024 Aug;
PMID: 39185522
Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms remain largely unknown. For a strong AD-associated...
2.
Shi Z, Wen K, Zou Z, Fu W, Guo K, Sammudin N, et al.
bioRxiv
. 2024 Aug;
PMID: 39149343
Animals adapt to environmental challenges with long-term changes at the behavioral, circuit, cellular, and synaptic levels which often require new protein synthesis. The discovery of reversible N6-methyladenosine (mA) modifications of...
3.
Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Sun X, et al.
Res Sq
. 2024 Jun;
PMID: 38826437
Despite genome-wide association studies of late-onset Alzheimer's disease (LOAD) having identified many genetic risk loci, the underlying disease mechanisms remain largely unknown. Determining causal disease variants and their LOAD-relevant cellular...
4.
Sudwarts A, Thinakaran G
Mol Neurodegener
. 2023 Nov;
18(1):90.
PMID: 37986179
Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer's disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be either harmful or protective. Herein, we...
5.
De Rossi P, Buggia-Prevot V, Clayton B, Vasquez J, van Sanford C, Andrew R, et al.
Mol Neurodegener
. 2023 Oct;
18(1):72.
PMID: 37784204
No abstract available.
6.
Aow J, Huang T, Goh Y, Sun A, Thinakaran G, Koo E
Cell Rep
. 2023 Jul;
42(7):112774.
PMID: 37450368
Amyloid precursor protein (APP) internalization via clathrin-/dynamin-mediated endocytosis (CME) mediated by its YENPTY motif into endosomes containing β-secretase is proposed to be critical for amyloid-beta (Aβ) production. Here, we show...
7.
Ulku I, Liebsch F, Akerman S, Schulz J, Kulic L, Hock C, et al.
Sci Rep
. 2023 Feb;
13(1):2216.
PMID: 36750595
The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its "amyloidogenic" activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an...
8.
Ponnusamy M, Wang S, Yuksel M, Hansen M, Blazier D, McMillan J, et al.
Brain
. 2022 Sep;
146(4):1561-1579.
PMID: 36059072
Bridging integrator 1 (BIN1) is the second most prevalent genetic risk factor identified by genome-wide association studies (GWAS) for late-onset Alzheimer's disease. BIN1 encodes an adaptor protein that regulates membrane...
9.
Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, et al.
Mol Neurodegener
. 2022 May;
17(1):33.
PMID: 35526014
Background: The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer's disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dynamics...
10.
Aow J, Huang T, Thinakaran G, Koo E
Mol Neurobiol
. 2022 Mar;
59(5):3073-3090.
PMID: 35266114
Background: Alzheimer's disease amyloid-beta peptides (Aβ) are generated via sequential cleavage of the amyloid precursor protein (APP) by β-secretase (Bace1) and γ-secretase. Though the precise subcellular location(s) of Bace1-mediated APP...