Gnana P Krishnamoorthy
Overview
Explore the profile of Gnana P Krishnamoorthy including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
754
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0
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Recent Articles
11.
Luckett K, Cracchiolo J, Krishnamoorthy G, Leandro-Garcia L, Nagarajah J, Saqcena M, et al.
Endocr Relat Cancer
. 2021 Apr;
28(6):391-402.
PMID: 33890869
Constitutive MAPK activation silences genes required for iodide uptake and thyroid hormone biosynthesis in thyroid follicular cells. Accordingly, most BRAFV600E papillary thyroid cancers (PTC) are refractory to radioiodide (RAI) therapy....
12.
Saqcena M, Leandro-Garcia L, Maag J, Tchekmedyian V, Krishnamoorthy G, Tamarapu P, et al.
Cancer Discov
. 2020 Dec;
11(5):1158-1175.
PMID: 33318036
Mutations of subunits of the SWI/SNF chromatin remodeling complexes occur commonly in cancers of different lineages, including advanced thyroid cancers. Here we show that thyroid-specific loss of , or in...
13.
Krishnamoorthy G, Davidson N, Leach S, Zhao Z, Lowe S, Lee G, et al.
Cancer Discov
. 2018 Oct;
9(2):264-281.
PMID: 30305285
Translation initiation is orchestrated by the cap binding and 43S preinitiation complexes (PIC). Eukaryotic initiation factor 1A (EIF1A) is essential for recruitment of the ternary complex and for assembling the...
14.
Untch B, Dos Anjos V, Garcia-Rendueles M, Knauf J, Krishnamoorthy G, Saqcena M, et al.
Cancer Res
. 2018 May;
78(16):4642-4657.
PMID: 29760048
Of the three RAS oncoproteins, only HRAS is delocalized and inactivated by farnesyltransferase inhibitors (FTI), an approach yet to be exploited clinically. In this study, we treat mice bearing Hras-driven...
15.
Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf J, Shah R, et al.
J Clin Invest
. 2016 Feb;
126(3):1052-66.
PMID: 26878173
Background: Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) are rare and frequently lethal tumors that so far have not been subjected to comprehensive genetic characterization. Methods: We...