Glen Spraggon
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Explore the profile of Glen Spraggon including associated specialties, affiliations and a list of published articles.
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107
Citations
2205
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Recent Articles
1.
DiDonato M, Simpson C, Vo T, Knuth M, Geierstanger B, Jamontt J, et al.
Structure
. 2025 Jan;
33(3):475-488.e7.
PMID: 39798572
Inflammatory bowel disease (IBD) consists of chronic conditions that severely impact a patient's health and quality of life. Interleukin-10 (IL-10), a potent anti-inflammatory cytokine has strong genetic links to IBD...
2.
Zhou Y, Cox J, Zhou B, Zhu S, Zhong Y, Spraggon G
Bioinformatics
. 2024 Nov;
40(12).
PMID: 39499140
Motivation: The advent of AlphaFold and other protein Artificial Intelligence (AI) models has transformed protein design, necessitating efficient handling of large-scale data and complex workflows. Using existing programming packages that...
3.
Menichelli E, Lam B, Wang Y, Wang V, Shaffer J, Tjhung K, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(48):e2213117119.
PMID: 36413497
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using small molecules. While there have been some successes in RNA-targeted small-molecule discovery, a deeper understanding of structure-activity relationships...
4.
Brousseau M, Clairmont K, Spraggon G, Flyer A, Golosov A, Grosche P, et al.
Cell Chem Biol
. 2021 Sep;
29(2):249-258.e5.
PMID: 34547225
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-C concentrations and...
5.
Kingsley L, He X, McNeill M, Nelson J, Nikulin V, Ma Z, et al.
J Med Chem
. 2021 Apr;
64(8):4857-4869.
PMID: 33821636
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents....
6.
Balakrishnan A, Price E, Luu C, Shaul J, Wartchow C, Cantwell J, et al.
ACS Infect Dis
. 2020 Sep;
6(10):2800-2811.
PMID: 32886480
RNA-dependent RNA polymerases (RdRPs) from nonsegmented negative strand (NNS) RNA viruses perform both mRNA transcription and genome replication, and these activities are regulated by their interactions with RNA and other...
7.
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, et al.
J Med Chem
. 2020 Jul;
63(19):10773-10781.
PMID: 32667203
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of...
8.
Harding D, Kingsley L, Spraggon G, Wheeler S
J Comput Chem
. 2020 Feb;
41(12):1175-1184.
PMID: 32011009
The convergence of DFT-computed interaction energies with increasing binding site model size was assessed. The data show that while accurate intercalator interaction energies can be derived from binding site models...
9.
Kingsley L, Brunet V, Lelais G, McCloskey S, Milliken K, Leija E, et al.
J Mol Graph Model
. 2019 Mar;
89:234-241.
PMID: 30921557
In drug discovery, structural knowledge of a target enables structure-based design approaches and thereby reduces the time and labor required to develop a therapy. Whilst molecular graphics frameworks coupled with...
10.
Maritan M, Veggi D, Cozzi R, Iacono L, Bartolini E, Lo Surdo P, et al.
PLoS One
. 2018 Aug;
13(8):e0201922.
PMID: 30133484
Neisserial heparin binding antigen (NHBA) is one of three main recombinant protein antigens in 4CMenB, a vaccine for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B....