Glen Spraggon
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Explore the profile of Glen Spraggon including associated specialties, affiliations and a list of published articles.
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107
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2205
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Recent Articles
11.
Pham G, Ou W, Bursulaya B, DiDonato M, Herath A, Jin Y, et al.
Chembiochem
. 2018 Feb;
19(8):799-804.
PMID: 29388367
Activated esters are widely used to label proteins at lysine side chains and N termini. These reagents are useful for labeling virtually any protein, but robust reactivity toward primary amines...
12.
Zhang Z, Ratnikov M, Spraggon G, Alper P
Angew Chem Int Ed Engl
. 2017 Dec;
57(4):904-908.
PMID: 29266649
The photoinduced rearrangement pathways of simple 2,5-dienones and the natural product santonin were found to be effectively rerouted by amines, giving rise to unprecedented products. Either cis olefins or cyclobutenes...
13.
He X, Da Ros S, Nelson J, Zhu X, Jiang T, Okram B, et al.
ACS Med Chem Lett
. 2017 Oct;
8(10):1048-1053.
PMID: 29057049
NOD2 (nucleotide-binding oligomerization domain-containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and stimulates host immune responses. Dysfunction of NOD2 pathway has been associated with a...
14.
Cellitti S, Shaffer J, Jones D, Mukherjee T, Gurumurthy M, Bursulaya B, et al.
Structure
. 2017 Sep;
21(1):191.
PMID: 28903033
No abstract available.
15.
Khare S, Nagle A, Biggart A, Lai Y, Liang F, Davis L, et al.
Nature
. 2016 Aug;
537(7619):229-233.
PMID: 27501246
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually. The diseases are caused by infection with the kinetoplastid parasites Trypanosoma...
16.
Lelais G, Epple R, Marsilje T, Long Y, McNeill M, Chen B, et al.
J Med Chem
. 2016 Jul;
59(14):6671-89.
PMID: 27433829
Over the past decade, first and second generation EGFR inhibitors have significantly improved outcomes for lung cancer patients with activating mutations in EGFR. However, both resistance through a secondary T790M...
17.
Park I, Venable J, Steckler C, Cellitti S, Lesley S, Spraggon G, et al.
J Chem Inf Model
. 2015 Aug;
55(9):1914-25.
PMID: 26241692
Hydrogen exchange (HX) studies have provided critical insight into our understanding of protein folding, structure, and dynamics. More recently, hydrogen exchange mass spectrometry (HX-MS) has become a widely applicable tool...
18.
Deller M, Johnson H, Miller M, Spraggon G, Elsliger M, Wilson I, et al.
PLoS One
. 2015 Apr;
10(3):e0122512.
PMID: 25826626
The TM1088 locus of T. maritima codes for two proteins designated TM1088A and TM1088B, which combine to form the cytosolic portion of a putative Trk K+ transporter. We report the...
19.
Malito E, Biancucci M, Faleri A, Ferlenghi I, Scarselli M, Maruggi G, et al.
Proc Natl Acad Sci U S A
. 2014 Nov;
111(48):17128-33.
PMID: 25404323
Serogroup B Neisseria meningitidis (MenB) is a major cause of severe sepsis and invasive meningococcal disease, which is associated with 5-15% mortality and devastating long-term sequelae. Neisserial adhesin A (NadA),...
20.
Grunewald J, Jones D, Brock A, Chiu H, Bursulaya B, Ng K, et al.
Chembiochem
. 2014 Jul;
15(12):1787-91.
PMID: 25044133
To expand the utility of proteinaceous FRET biosensors, we have developed a dual-labeling approach based on two small bio-orthogonal tags: pyrroline-carboxy-lysine (Pcl) and the S6 peptide. The lack of cross-reactivity...