Gino B Ferraro
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Explore the profile of Gino B Ferraro including associated specialties, affiliations and a list of published articles.
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39
Citations
2234
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Recent Articles
11.
Valiente M, Van Swearingen A, Anders C, Bairoch A, Boire A, Bos P, et al.
Cancer Res
. 2020 Jul;
80(20):4314-4323.
PMID: 32641416
Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma most notably. Although...
12.
Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang R, et al.
Cancer Discov
. 2020 Jun;
10(9):1352-1373.
PMID: 32571778
A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine-limited brain environment restrict metastatic tumor growth. How brain metastases...
13.
Arvanitis C, Ferraro G, Jain R
Nat Rev Cancer
. 2019 Oct;
20(1):26-41.
PMID: 31601988
For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel wall to reach cancer cells in adequate quantities, and it must overcome the resistance conferred...
14.
Seano G, Nia H, Emblem K, Datta M, Ren J, Krishnan S, et al.
Nat Biomed Eng
. 2019 Apr;
3(3):230-245.
PMID: 30948807
The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the biological consequences...
15.
Askoxylakis V, Ferraro G, Badeaux M, Kodack D, Kirst I, Shankaraiah R, et al.
NPJ Breast Cancer
. 2019 Jan;
5:4.
PMID: 30675514
The effective treatment of cerebral metastases from HER2-positive breast cancer remains an unmet need. Recent studies indicate that activated astrocytes and brain endothelial cells exert chemoprotective effects on cancer cells...
16.
Keklikoglou I, Cianciaruso C, Guc E, Squadrito M, Spring L, Tazzyman S, et al.
Nat Cell Biol
. 2019 Jan;
21(2):190-202.
PMID: 30598531
Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes,...
17.
Arvanitis C, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro G, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(37):E8717-E8726.
PMID: 30150398
Blood-brain/blood-tumor barriers (BBB and BTB) and interstitial transport may constitute major obstacles to the transport of therapeutics in brain tumors. In this study, we examined the impact of focused ultrasound...
18.
Zhao Y, Liu P, Zhang N, Chen J, Landegger L, Wu L, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(9):E2077-E2084.
PMID: 29440379
Neurofibromatosis type II (NF2) is a disease that needs new solutions. Vestibular schwannoma (VS) growth causes progressive hearing loss, and the standard treatment, including surgery and radiotherapy, can further damage...
19.
Sanz R, Ferraro G, Kacervosky J, Salesse C, Gowing E, Hua L, et al.
J Neurosci
. 2017 Dec;
38(3):518-529.
PMID: 29196321
Cell-surface molecules are dynamically regulated at the synapse to assemble and disassemble adhesive contacts that are important for synaptogenesis and for tuning synaptic transmission. Metalloproteinases dynamically regulate cellular behaviors through...
20.
Askoxylakis V, Badeaux M, Roberge S, Batista A, Kirkpatrick N, Snuderl M, et al.
Nat Protoc
. 2017 Oct;
12(11):2251-2262.
PMID: 28981123
The cerebellum is a prominent part of the vertebrate hindbrain that is critically involved in the regulation of important body functions such as movement coordination, maintenance of balance and posture,...