Alyson E Fournier
Overview
Explore the profile of Alyson E Fournier including associated specialties, affiliations and a list of published articles.
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62
Citations
1773
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Recent Articles
1.
Drake S, Mohammadnia A, Zaman A, Gianfelice C, Heale K, Groh A, et al.
Cell Rep
. 2025 Feb;
44(2):115298.
PMID: 39937646
In multiple sclerosis (MS), inflammation of the central nervous system results in demyelination, neuroaxonal injury, and cell death. However, the molecular signals responsible for injury and cell death in neurons...
2.
Drake S, Zaman A, Gianfelice C, Hua E, Heale K, Afanasiev E, et al.
J Neuroinflammation
. 2024 Nov;
21(1):283.
PMID: 39487537
Background: The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent cells improves outcomes in a variety of contexts particularly related to...
3.
Hintermayer M, Juzwik C, Morquette B, Hua E, Zhang J, Drake S, et al.
J Neurosci
. 2024 Sep;
44(44).
PMID: 39266301
Neuroinflammation can positively influence axon regeneration following injury in the central nervous system. Inflammation promotes the release of neurotrophic molecules and stimulates intrinsic proregenerative molecular machinery in neurons, but the...
4.
Groh A, Caporicci-Dinucci N, Afanasiev E, Bigotte M, Lu B, Gertsvolf J, et al.
J Neurochem
. 2024 May;
168(10):3449-3466.
PMID: 38702968
Ependymal cells form a specialized brain-cerebrospinal fluid (CSF) interface and regulate local CSF microcirculation. It is becoming increasingly recognized that ependymal cells assume a reactive state in response to aging...
5.
Drake S, Mohammadnia A, Heale K, Groh A, Hua E, Zaman A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873446
In multiple sclerosis (MS), the invasion of the central nervous system by peripheral immune cells is followed by the activation of resident microglia and astrocytes. This cascade of events results...
6.
Drake S, Zaman A, Simas T, Fournier A
WIREs Mech Dis
. 2023 Jan;
15(2):e1594.
PMID: 36600404
Central nervous system (CNS) inflammation is a key factor in multiple sclerosis (MS). Invasion of peripheral immune cells into the CNS resulting from an unknown signal or combination of signals...
7.
Drake S, Charabati M, Simas T, Xu Y, Maes E, Shi S, et al.
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499143
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease driven by inflammation and demyelination in the brain, spinal cord, and optic nerve. Optic neuritis, characterized by inflammation and demyelination of...
8.
Woller S, Ruschel J, Morquette B, Cardia J, Yan D, Holton K, et al.
iScience
. 2022 May;
25(6):104379.
PMID: 35620420
The therapeutic use of RNAi has grown but often faces several hurdles related to delivery systems, compound stability, immune activation, and on-target/off-tissue effects. Self-delivering RNAi (sdRNA) molecules do not require...
9.
Hintermayer M, Drake S, Fournier A
Neuron
. 2021 Nov;
109(21):3395-3397.
PMID: 34735789
In this issue of Neuron, Stern et al. (2021) demonstrate that cell-type-specific ablation of RhoA differentially affects axon regeneration outcomes in spinal cord injury models. Their findings highlight the importance...
10.
Kaplan A, Andrei S, van Regteren Altena A, Simas T, Banerjee S, Kato N, et al.
Cell Chem Biol
. 2020 Mar;
27(6):657-667.e6.
PMID: 32220335
Targeting protein-protein interactions (PPIs) is a promising approach in the development of drugs for many indications. 14-3-3 proteins are a family of phosphoprotein-binding molecules with critical functions in dozens of...