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» Authors » Ginamarie Debevec

Ginamarie Debevec

Explore the profile of Ginamarie Debevec including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 134
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Richard A Houghten
Marc A Giulianotti
Radleigh G Santos
Clemencia Pinilla
Skye R Doering
Carrie Haskell-Luevano
Phaedra Geer
Marc Giulianotti
Jon R Appel
Yongping Yu
Published In
J Med Chem
ACS Comb Sci
Eur J Med Chem
Front Microbiol
ACS Chem Biol
Affiliations
Soon will be listed here.
Recent Articles
1.
Correction to "Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign"
Doering S, Freeman K, Debevec G, Geer P, Santos R, Lavoi T, et al.
J Med Chem . 2023 May; 66(10):7063-7065. PMID: 37155917
No abstract available.
2.
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign
Doering S, Freeman K, Debevec G, Geer P, Santos R, Lavoi T, et al.
J Med Chem . 2021 Apr; 64(9):5577-5592. PMID: 33886285
The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators of body weight and energy homeostasis. Herein, the discovery and characterization of first-in-class small molecule melanocortin agonists with selectivity...
3.
A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A
Cho E, Devkota A, Stancu G, Edupunganti R, Debevec G, Giulianotti M, et al.
SLAS Discov . 2020 May; 25(9):1038-1046. PMID: 32462959
Hypoxic solid tumors induce the stabilization of hypoxia-inducible factor 1 alpha (HIF1α), which stimulates the expression of many glycolytic enzymes and hypoxia-responsive genes. A high rate of glycolysis supports the...
4.
Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency
Zhang X, Santos R, Debevec G, Li D, Schutte R, Pham K, et al.
Biochem Biophys Res Commun . 2020 May; 527(1):317-323. PMID: 32446387
This study aimed to identify small molecules that have the potential to treat alpha1-antitrypsin deficiency (AATD) by screening compounds available from a mixture-based scaffold library. 93 scaffold libraries (total diversity...
5.
A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation
Sammons R, Perry N, Li Y, Cho E, Piserchio A, Zamora-Olivares D, et al.
ACS Chem Biol . 2019 May; 14(6):1183-1194. PMID: 31058487
Extracellular signal-regulated kinases (ERK1/2) are mitogen-activated protein kinases (MAPKs) that play a pro-tumorigenic role in numerous cancers. ERK1/2 possess two protein-docking sites that are distinct from the active site: the...
6.
Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries
Perry Jr D, Roberts B, Debevec G, Michaels H, Chakrabarti D, Nefzi A
Molecules . 2019 Mar; 24(6). PMID: 30897744
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the...
7.
Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial Agonist
Fleming K, Freeman K, Powers M, Santos R, Debevec G, Giulianotti M, et al.
J Med Chem . 2019 Feb; 62(5):2738-2749. PMID: 30741545
The centrally expressed melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R, respectively) are established targets to treat diseases of positive- and negative-energy homeostasis. We previously reported [ Doering , S. R....
8.
Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency
Al-Ali H, Debevec G, Santos R, Houghten R, Davis J, Nefzi A, et al.
ACS Med Chem Lett . 2018 Oct; 9(10):1057-1062. PMID: 30344917
Central nervous system (CNS) neurons typically fail to regrow their axons after injury. Injuries or neuropathies that damage CNS axons and disrupt neuronal circuitry often result in permanent functional deficits....
9.
Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens
Fleeman R, Debevec G, Antonen K, Adams J, Santos R, Welmaker G, et al.
Front Microbiol . 2018 Jul; 9:1301. PMID: 29963035
We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this technology toward the discovery of anti-resistance molecules, focusing on...
10.
Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries
Tran T, Chiem K, Jani S, Arivett B, Lin D, Lad R, et al.
Int J Antimicrob Agents . 2018 Feb; 51(5):752-761. PMID: 29410367
The aminoglycoside, 6'-N-acetyltransferase type Ib [AAC(6')-Ib] is the most widely distributed enzyme among AAC(6')-I-producing Gram-negative pathogens and confers resistance to clinically relevant aminoglycosides, including amikacin. This enzyme is therefore an...