Ghulam M Maharvi
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Explore the profile of Ghulam M Maharvi including associated specialties, affiliations and a list of published articles.
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17
Citations
299
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Recent Articles
1.
Maharvi G, Bharucha A, Fauq A
Bioorg Med Chem Lett
. 2013 Mar;
23(9):2808-11.
PMID: 23511016
Magnetic resonance imaging (MRI) is used to evaluate gastrointestinal (GI) structure and functions in humans. Despite filling the viscus lumen with a contrast agent, visualization of the viscus wall is...
2.
Beri V, Auletta J, Maharvi G, Wood J, Fauq A, Rosenberry T
Chem Biol Interact
. 2012 Oct;
203(1):38-43.
PMID: 23047027
Hydrolysis of acetylcholine by acetylcholinesterase (AChE) is extremely rapid, with a second-order hydrolysis rate constant k(E) (often denoted k(cat)/K(M)) that approaches 10(8) M(-1) s(-1). AChE contains a deep active site...
3.
Bourassa P, Dubeau S, Maharvi G, Fauq A, Thomas T, Tajmir-Riahi H
Eur J Med Chem
. 2011 Jul;
46(9):4344-53.
PMID: 21777996
The breast anticancer drug tamoxifen and its metabolites bind serum albumins. We located the binding sites of tamoxifen, 4-hydroxytamoxifen and endoxifen on bovine serum albumin (BSA). FTIR, CD and fluorescence...
4.
Bourassa P, Dubeau S, Maharvi G, Fauq A, Thomas T, Tajmir-Riahi H
Biochimie
. 2011 Mar;
93(7):1089-101.
PMID: 21439346
Tamoxifen is extensively metabolized, and several metabolites have been detected in human serum. The aim of this study was to examine the interaction of human serum albumin (HSA) with tamoxifen...
5.
Maharvi G, Edwards A, Fauq A
Tetrahedron Lett
. 2010 Nov;
51(49):6426-6428.
PMID: 21076635
First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, C34:5n5.d(2), and three other unlabeled very long chain C30-32-containing polyunsaturated fatty acids are reported here. These syntheses were achieved...
6.
Leissring M, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay S, et al.
PLoS One
. 2010 May;
5(5):e10504.
PMID: 20498699
Background: Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it should be possible to...
7.
Fauq A, Maharvi G, Sinha D
Bioorg Med Chem Lett
. 2010 Apr;
20(10):3036-8.
PMID: 20400308
A mixture of the (Z)- and (E)-isomers of 4-hydroxy-N-desmethyltamoxifen was conveniently prepared in four steps. These geometrical isomers were then neatly separated by semi-preparative Reverse Phase High Performance Liquid Chromatography...
8.
Rangachari V, Davey Z, Healy B, Moore B, Sonoda L, Cusack B, et al.
Biopolymers
. 2009 Feb;
91(6):456-65.
PMID: 19189374
Among the pathological hallmarks of Alzheimer's disease (AD) is the deposition of amyloid-beta (Abeta) peptides, primarily Abeta (1-40) and Abeta (1-42), in the brain as senile plaques. A large body...
9.
Kukar T, Ladd T, Bann M, Fraering P, Narlawar R, Maharvi G, et al.
Nature
. 2008 Jun;
453(7197):925-9.
PMID: 18548070
Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's...
10.
Maharvi G, Ali S, Riaz N, Afza N, Malik A, Ashraf M, et al.
J Enzyme Inhib Med Chem
. 2008 Mar;
23(1):62-9.
PMID: 18341255
A mild and efficient route to tetraketones (2-22) has been developed by way of tetraethyl ammonium bromide (Et(4)N(+)Br(- )) mediated condensation of dimedone (5,5-dimethylcyclohexane-1,3-dione, 1) with a variety of aldehydes....