Gertrud M Hjorto
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Explore the profile of Gertrud M Hjorto including associated specialties, affiliations and a list of published articles.
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20
Citations
247
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Recent Articles
1.
Goth C, Mehta A, McQuillan A, Baker K, Hanes M, Park S, et al.
Cell Chem Biol
. 2023 Jul;
30(8):893-905.e7.
PMID: 37463583
Protein glycosylation influences cellular recognition and regulates protein interactions, but how glycosylation functions alongside other common posttranslational modifications (PTMs), like tyrosine sulfation (sTyr), is unclear. We produced a library of...
2.
Kjaer V, Daugvilaite V, Stepniewski T, Madsen C, Jorgensen A, Bhuskute K, et al.
Sci Signal
. 2023 Apr;
16(779):eabl4283.
PMID: 37014928
The chemotactic G protein-coupled receptor GPR183 and its most potent endogenous oxysterol ligand 7α,25-dihydroxycholesterol (7α,25-OHC) are important for immune cell positioning in secondary lymphoid tissues. This receptor-ligand pair is associated...
3.
Verhallen L, Lackman J, Wendt R, Gustavsson M, Yang Z, Narimatsu Y, et al.
Cell Mol Life Sci
. 2023 Feb;
80(2):55.
PMID: 36729338
Chemokine ligands and receptors regulate the directional migration of leukocytes. Post-translational modifications of chemokine receptors including O-glycosylation and tyrosine sulfation have been reported to regulate ligand binding and resulting signaling....
4.
Jensen S, Paerregaard S, Brandum E, Jorgensen A, Hjorto G, Jensen B
Gastroenterol Rep (Oxf)
. 2022 Mar;
10(1):goac008.
PMID: 35291443
Organismal survival depends on a well-balanced immune system and maintenance of host-microbe mutualism. The fine-tuned relationship between the gut microbiota and host immunity is constantly challenged by opportunistic bacteria testing...
5.
van der Velden W, Smit F, Christiansen C, Moller T, Hjorto G, Larsen O, et al.
ACS Pharmacol Transl Sci
. 2021 Feb;
4(1):296-313.
PMID: 33615180
Biased ligands that selectively confer activity in one pathway over another are pharmacologically important because biased signaling may reduce on-target side effects and improve drug efficacy. Here, we describe an...
6.
Moussouras N, Hjorto G, Peterson F, Szpakowska M, Chevigne A, Rosenkilde M, et al.
Biochemistry
. 2020 Mar;
59(13):1338-1350.
PMID: 32182428
The chemokines CCL21 and CCL19, through binding of their cognate receptor CCR7, orchestrate lymph node homing of dendritic cells and naïve T cells. CCL21 differs from CCL19 via an unstructured...
7.
Spiess K, Bagger S, Torz L, Jensen K, Walser A, Kvam J, et al.
Ann N Y Acad Sci
. 2019 Oct;
1456(1):186-199.
PMID: 31659746
The orphan receptor GPR125 (ADGRA3) belongs to subgroup III of the adhesion G protein-coupled receptor (aGPCR) family. aGPCRs, also known as class B2 GPCRs, share basic structural and functional properties...
8.
Jorgensen A, Larsen O, Uetz-von Allmen E, Luckmann M, Legler D, Frimurer T, et al.
Front Immunol
. 2019 Oct;
10:2156.
PMID: 31572374
Chemokine receptors play important roles in the immune system and are linked to several human diseases. Targeting chemokine receptors have so far shown very little success owing to, to some...
9.
Amarandi R, Luckmann M, Melynis M, Jakobsen M, Fallah Z, Spiess K, et al.
Eur J Med Chem
. 2018 Jun;
155:244-254.
PMID: 29886326
US28 is a broad-spectrum constitutively active G protein-coupled receptor encoded by the human cytomegalovirus (HCMV). It binds and scavenges multiple CC-chemokines as well as CXCL1 (fractalkine) by constitutive receptor endocytosis...
10.
Miles T, Spiess K, Jude K, Tsutsumi N, Burg J, Ingram J, et al.
Elife
. 2018 Jun;
7.
PMID: 29882741
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink' to facilitate evasion of host immune responses. To probe the molecular...