Thomas N Kledal
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Explore the profile of Thomas N Kledal including associated specialties, affiliations and a list of published articles.
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17
Citations
514
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Recent Articles
1.
Sund J, Bollerup S, Glamann J, Vinten C, Jensen L, Toft-Bethelsen T, et al.
Ugeskr Laeger
. 2022 Jun;
184(24).
PMID: 35703076
Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far...
2.
Ribeiro R, Ku T, Wang A, Pires L, Ferreira V, Michaelsen V, et al.
J Heart Lung Transplant
. 2021 Nov;
41(3):287-297.
PMID: 34802874
Background: Transmission of latent human cytomegalovirus (HCMV) via organ transplantation with post-transplant viral reactivation is extremely prevalent and results in substantial adverse impact on outcomes. Therapies targeting the latent reservoir...
3.
Fares S, Spiess K, Olesen E, Zuo J, Jackson S, Kledal T, et al.
mBio
. 2019 Jan;
10(1).
PMID: 30647152
The Epstein-Barr virus (EBV) BILF1 gene encodes a constitutively active G protein-coupled receptor (GPCR) that downregulates major histocompatibility complex (MHC) class I and induces signaling-dependent tumorigenesis. Different BILF1 homologs display...
4.
Spiess K, Jeppesen M, Malmgaard-Clausen M, Krzywkowski K, Kledal T, Rosenkilde M
J Immunol Res
. 2017 Mar;
2017:4069260.
PMID: 28251165
Immunotoxins as antiviral therapeutics are largely unexplored but have promising prospective due to their high selectivity potential and their unparalleled efficiency. One recent example targeted the virus-encoded G protein-coupled receptor...
5.
Spiess K, Jakobsen M, Kledal T, Rosenkilde M
J Leukoc Biol
. 2016 Jan;
99(6):911-25.
PMID: 26729815
There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral...
6.
Spiess K, Jeppesen M, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, et al.
Proc Natl Acad Sci U S A
. 2015 Jun;
112(27):8427-32.
PMID: 26080445
The use of receptor-ligand interactions to direct toxins to kill diseased cells selectively has shown considerable promise for treatment of a number of cancers and, more recently, autoimmune disease. Here...
7.
Hjorto G, Kiilerich-Pedersen K, Selmeczi D, Kledal T, Larsen N
J Gen Virol
. 2013 Jan;
94(Pt 5):1111-1120.
PMID: 23303826
Human cytomegalovirus (HCMV)-encoded G protein-coupled-receptor US28 is believed to participate in virus dissemination through modulation of cell migration and immune evasion. US28 binds different CC chemokines and the CX3C chemokine...
8.
Farrell H, Abraham A, Cardin R, Sparre-Ulrich A, Rosenkilde M, Spiess K, et al.
J Virol
. 2011 Apr;
85(12):6091-5.
PMID: 21490099
The human cytomegalovirus (CMV) proteins US28 and UL33 are homologous to chemokine receptors (CKRs). Knockout of the mouse CMV M33 protein (UL33 homologue) results in substantial attenuation of salivary gland...
9.
Hjorto G, Hansen M, Larsen N, Kledal T
Biomaterials
. 2009 Jul;
30(29):5305-11.
PMID: 19577290
Microcontact printing (mCP) is employed to generate discontinuous microscale gradients of active fractalkine, a chemokine expressed by endothelial cells near sites of inflammation where it is believed to form concentration...
10.
Rosenkilde M, Benned-Jensen T, Andersen H, Holst P, Kledal T, Luttichau H, et al.
J Biol Chem
. 2006 Mar;
281(19):13199-13208.
PMID: 16540462
Epstein-Barr virus (EBV)-induced receptor 2 (EBI2) is an orphan seven-transmembrane (7TM) receptor originally identified as the most up-regulated gene (>200-fold) in EBV-infected cells. Here we show that EBI2 signals with...