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Germana Falcone

Explore the profile of Germana Falcone including associated specialties, affiliations and a list of published articles. Areas
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Articles 21
Citations 461
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Recent Articles
11.
Cappella M, Perfetti A, Cardinali B, Garcia-Manteiga J, Carrara M, Provenzano C, et al.
Cell Death Dis . 2018 Jun; 9(7):729. PMID: 29955039
Myotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by abnormally expanded stretches of CTG DNA triplets in the DMPK gene, leading to mutated-transcript RNA-toxicity. MicroRNAs (miRNAs) are short...
12.
Provenzano C, Cappella M, Valaperta R, Cardani R, Meola G, Martelli F, et al.
Mol Ther Nucleic Acids . 2017 Dec; 9:337-348. PMID: 29246312
Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy, characterized by progressive myopathy, myotonia, and multi-organ involvement. This dystrophy is an inherited autosomal dominant disease caused by...
13.
Falcone G, Felsani A, DAgnano I
J Exp Clin Cancer Res . 2015 Apr; 34:32. PMID: 25886763
A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great attention in cancer research since they play a central role in regulation of gene-expression and miRNA aberrant...
14.
Biferi M, Nicoletti C, Falcone G, Puggioni E, Passaro N, Mazzola A, et al.
Mol Ther . 2015 Feb; 23(5):885-895. PMID: 25669433
Although in the last decades the molecular underpinnings of the cell cycle have been unraveled, the acquired knowledge has been rarely translated into practical applications. Here, we investigate the feasibility...
15.
Falcone G, Perfetti A, Cardinali B, Martelli F
Biomed Res Int . 2014 Apr; 2014:503634. PMID: 24729974
The fascinating world of noncoding RNAs has recently come to light, thanks to the development of powerful sequencing technologies, revealing a variety of RNA molecules playing important regulatory functions in...
16.
De Luca G, Ventura I, Sanghez V, Russo M, Ajmone-Cat M, Cacci E, et al.
Aging Cell . 2013 May; 12(4):695-705. PMID: 23648059
The contribution that oxidative damage to DNA and/or RNA makes to the aging process remains undefined. In this study, we used the hMTH1-Tg mouse model to investigate how oxidative damage...
17.
Falcone G, Mazzola A, Michelini F, Bossi G, Censi F, Biferi M, et al.
Aging Cell . 2012 Nov; 12(2):312-5. PMID: 23167636
Senescence is thought to be triggered by DNA damage, usually indirectly assessed as activation of the DNA damage response (DDR), but direct surveys of genetic damage are lacking. Here, we...
18.
Cardinali B, Castellani L, Fasanaro P, Basso A, Alema S, Martelli F, et al.
PLoS One . 2009 Oct; 4(10):e7607. PMID: 19859555
Background: MicroRNAs (miRNAs) are a class of small non-coding RNAs that have recently emerged as important regulators of gene expression. They negatively regulate gene expression post-transcriptionally by translational repression and...
19.
Castellani L, Salvati E, Alema S, Falcone G
J Biol Chem . 2006 Apr; 281(22):15249-57. PMID: 16574652
The RhoA GTPase controls a variety of cell functions such as cell motility, cell growth, and gene expression. Previous studies suggested that RhoA mediates signaling inputs that promote skeletal myogenic...
20.
Falcone G, Ciuffini L, Gauzzi M, Provenzano C, Strano S, Gallo R, et al.
Oncogene . 2003 Nov; 22(51):8302-15. PMID: 14614454
The conversion of skeletal myoblasts to terminally differentiated myocytes is negatively controlled by several growth factors and oncoproteins. In this study, we have investigated the molecular mechanisms by which v-Src,...