Gerd Multhaup
Overview
Explore the profile of Gerd Multhaup including associated specialties, affiliations and a list of published articles.
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75
Citations
2465
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0
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Recent Articles
1.
Achazi K, Haag R, Ballauff M, Dernedde J, Kizhakkedathu J, Maysinger D, et al.
Angew Chem Int Ed Engl
. 2020 Jun;
60(8):3882-3904.
PMID: 32589355
The counterions neutralizing the charges on polyelectrolytes such as DNA or heparin may dissociate in water and greatly influence the interaction of such polyelectrolytes with biomolecules, particularly proteins. In this...
2.
Engelke A, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, et al.
J Biol Chem
. 2018 Apr;
293(21):8020-8031.
PMID: 29636413
A central step in the pathogenesis of prion diseases is the conformational transition of the cellular prion protein (PrP) into the scrapie isoform, denoted PrP Studies in transgenic mice have...
3.
Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al.
J Biol Chem
. 2017 Jun;
292(32):13258-13270.
PMID: 28637867
The β-secretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Aβ peptides, which have been implicated as central players in the pathology of Alzheimer disease. BACE1 has been...
4.
Schafer S, Pajonk F, Multhaup G, Bayer T
J Mol Med (Berl)
. 2016 Aug;
85(4):421.
PMID: 27517708
No abstract available.
5.
Prade E, Barucker C, Sarkar R, Althoff-Ospelt G, Lopez Del Amo J, Hossain S, et al.
Biochemistry
. 2016 Feb;
55(12):1839-49.
PMID: 26900939
Alzheimer's disease is characterized by deposition of the amyloid β-peptide (Aβ) in brain tissue of affected individuals. In recent years, many potential lead structures have been suggested that can potentially...
6.
Prade E, Bittner H, Sarkar R, Lopez Del Amo J, Althoff-Ospelt G, Multhaup G, et al.
J Biol Chem
. 2015 Sep;
290(48):28737-45.
PMID: 26416887
Alzheimer disease is the most severe neurodegenerative disease worldwide. In the past years, a plethora of small molecules interfering with amyloid-β (Aβ) aggregation has been reported. However, their mode of...
7.
Dahms S, Mayer M, Roeser D, Multhaup G, Than M
Acta Crystallogr D Biol Crystallogr
. 2015 Mar;
71(Pt 3):494-504.
PMID: 25760599
Beyond the pathology of Alzheimer's disease, the members of the amyloid precursor protein (APP) family are essential for neuronal development and cell homeostasis in mammals. APP and its paralogues APP-like...
8.
Fehse S, Nowag S, Quadir M, Kim K, Haag R, Multhaup G
Biomacromolecules
. 2014 Apr;
15(5):1910-9.
PMID: 24725062
Copper (Cu) is a cofactor of various metalloenzymes and has a role in neurodegenerative diseases with disturbed Cu homeostasis, for example, in Alzheimer's disease (AD) and Menkes disease. To address...
9.
Munter L, Sieg H, Bethge T, Liebsch F, Bierkandt F, Schleeger M, et al.
J Am Chem Soc
. 2013 Dec;
135(51):19354-61.
PMID: 24304299
The β-secretase or β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the enzyme responsible for the formation of amyloid-β peptides, which have a major role in Alzheimer pathogenesis. BACE1...
10.
Olsson F, Schmidt S, Althoff V, Munter L, Jin S, Rosqvist S, et al.
J Biol Chem
. 2013 Nov;
289(3):1540-50.
PMID: 24225948
Processing of the amyloid precursor protein (APP) by γ-secretase results in generation of Aβ peptides of different lengths ranging from 51 to 30 residues. Accumulation of Aβ and in particular...