Gerd Multhaup
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Explore the profile of Gerd Multhaup including associated specialties, affiliations and a list of published articles.
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75
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2465
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Recent Articles
11.
Pester O, Gotz A, Multhaup G, Scharnagl C, Langosch D
Chembiochem
. 2013 Oct;
14(15):1943-8.
PMID: 24115334
Wobbly backbone: The backbone dynamics of the amyloid precursor protein (APP) transmembrane helix was compared to those of other transmembrane domains. In contrast to expectation, no above-average backbone dynamics was...
12.
Holzhauser S, Freiwald A, Weise C, Multhaup G, Han C, Sauer S
Angew Chem Int Ed Engl
. 2013 Apr;
52(19):5171-4.
PMID: 23568553
No abstract available.
13.
Badiola N, Alcalde V, Pujol A, Munter L, Multhaup G, Lleo A, et al.
PLoS One
. 2013 Mar;
8(3):e58837.
PMID: 23520537
A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein...
14.
Hoppmann C, Barucker C, Lorenz D, Multhaup G, Beyermann M
Chembiochem
. 2012 Nov;
13(18):2657-60.
PMID: 23161824
Aggregation of amyloid β (Aβ(1-42)), causing toxicity, is a critical step in Alzheimer's disease (AD). AD studies are difficult to compare because Aβ(1-42) aggregation is poorly controllable under physiological conditions....
15.
Resenberger U, Muller V, Munter L, Baier M, Multhaup G, Wilson M, et al.
J Biol Chem
. 2012 Nov;
287(52):43765-76.
PMID: 23115236
The heat shock response (HSR) is an evolutionarily conserved pathway designed to maintain proteostasis and to ameliorate toxic effects of aberrant protein folding. We have studied the modulation of the...
16.
17.
Bien J, Jefferson T, Causevic M, Jumpertz T, Munter L, Multhaup G, et al.
J Biol Chem
. 2012 Aug;
287(40):33304-13.
PMID: 22879596
The amyloid β (Aβ) peptide, which is abundantly found in the brains of patients suffering from Alzheimer disease, is central in the pathogenesis of this disease. Therefore, to understand the...
18.
Esselens C, Sannerud R, Gallardo R, Baert V, Kaden D, Serneels L, et al.
FASEB J
. 2012 Jun;
26(9):3765-78.
PMID: 22661005
Presenilins (PSENs) form the catalytic component of the γ-secretase complex, responsible for intramembrane proteolysis of amyloid precursor protein (APP) and Notch, among many other membrane proteins. Previously, we identified a...
19.
Kaden D, Harmeier A, Weise C, Munter L, Althoff V, Rost B, et al.
EMBO Mol Med
. 2012 Apr;
4(7):647-59.
PMID: 22514144
Here, we describe a novel missense mutation in the amyloid precursor protein (APP) causing a lysine-to-asparagine substitution at position 687 (APP770; herein, referred to as K16N according to amyloid-β (Aβ)...
20.
Dahms S, Konnig I, Roeser D, Guhrs K, Mayer M, Kaden D, et al.
J Mol Biol
. 2012 Jan;
416(3):438-52.
PMID: 22245578
The amyloid precursor protein (APP) and its neurotoxic cleavage product Aβ are key players in the development of Alzheimer's disease and appear essential for neuronal development and cell homeostasis in...