Gerard J P van Westen
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Explore the profile of Gerard J P van Westen including associated specialties, affiliations and a list of published articles.
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96
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1083
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Recent Articles
11.
Beerkens B, Andrianopoulou V, Wang X, Liu R, van Westen G, Jespers W, et al.
ACS Chem Biol
. 2024 Jun;
19(7):1554-1562.
PMID: 38920052
Small molecular tool compounds play an essential role in the study of G protein-coupled receptors (GPCRs). However, tool compounds most often occupy the orthosteric binding site, hampering the study of...
12.
Dilweg M, Gorostiola Gonzalez M, de Ruiter M, Meijboom N, Veldhoven J, Liu R, et al.
Purinergic Signal
. 2024 Jun;
PMID: 38879664
The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport of nucleosides and nucleobases, such as adenosine. This nucleoside regulates various physiological processes,...
13.
Gorostiola Gonzalez M, Rakers P, Jespers W, IJzerman A, Heitman L, van Westen G
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612509
Cancer remains a leading cause of mortality worldwide and calls for novel therapeutic targets. Membrane proteins are key players in various cancer types but present unique challenges compared to soluble...
14.
Veggel L, Mocking T, Sijben H, Liu R, Gorostiola Gonzalez M, Dilweg M, et al.
ACS Chem Neurosci
. 2024 Mar;
15(7):1424-1431.
PMID: 38478848
Excitatory amino acid transporters (EAATs) are important regulators of amino acid transport and in particular glutamate. Recently, more interest has arisen in these transporters in the context of neurodegenerative diseases....
15.
Gorostiola Gonzalez M, Sijben H, Dall Acqua L, Liu R, IJzerman A, Heitman L, et al.
Front Mol Biosci
. 2023 Dec;
10:1286673.
PMID: 38074092
Glutamate is an essential excitatory neurotransmitter and an intermediate for energy metabolism. Depending on the tumor site, cancer cells have increased or decreased expression of excitatory amino acid transporter 1...
16.
Martens M, Stierum R, Schymanski E, Evelo C, Aalizadeh R, Aladjov H, et al.
F1000Res
. 2023 Oct;
10.
PMID: 37842337
Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models...
17.
Mullowney M, Duncan K, Elsayed S, Garg N, van der Hooft J, Martin N, et al.
Nat Rev Drug Discov
. 2023 Sep;
22(11):895-916.
PMID: 37697042
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as...
18.
Houvast R, Badr N, March T, de Muynck L, Sier V, Schomann T, et al.
Eur J Nucl Med Mol Imaging
. 2023 Aug;
51(8):2179-2192.
PMID: 37642704
Purpose: Fluorescence-guided surgery (FGS) can play a key role in improving radical resection rates by assisting surgeons to gain adequate visualization of malignant tissue intraoperatively. Designed ankyrin repeat proteins (DARPins)...
19.
Gorostiola Gonzalez M, van den Broek R, Braun T, Chatzopoulou M, Jespers W, IJzerman A, et al.
J Cheminform
. 2023 Aug;
15(1):74.
PMID: 37641107
Proteochemometric (PCM) modelling is a powerful computational drug discovery tool used in bioactivity prediction of potential drug candidates relying on both chemical and protein information. In PCM features are computed...
20.
Bequignon O, Gomez-Tamayo J, Lenselink E, Wink S, Hiemstra S, Lam C, et al.
J Chem Inf Model
. 2023 Aug;
63(17):5433-5445.
PMID: 37616385
Oxidative stress is the consequence of an abnormal increase of reactive oxygen species (ROS). ROS are generated mainly during the metabolism in both normal and pathological conditions as well as...