Gerald L Hazelbauer
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Explore the profile of Gerald L Hazelbauer including associated specialties, affiliations and a list of published articles.
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41
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1546
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Recent Articles
1.
Hathcock D, Yu Q, Mello B, Amin D, Hazelbauer G, Tu Y
Proc Natl Acad Sci U S A
. 2023 Oct;
120(42):e2303115120.
PMID: 37824527
The chemotaxis signaling pathway has served as a model system for the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity of CheA in...
2.
Hathcock D, Yu Q, Mello B, Amin D, Hazelbauer G, Tu Y
ArXiv
. 2023 Mar;
PMID: 36866223
The Escherichia coli chemotaxis signaling pathway has served as a model system for studying the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity...
3.
Li M, Xu X, Zou X, Hazelbauer G
mBio
. 2021 Nov;
12(6):e0310621.
PMID: 34809457
Methylesterase/deamidase CheB is a key component of bacterial chemotaxis systems. It is also a prominent example of a two-component response regulator in which the effector domain is an enzyme. Like...
4.
Gordon J, Hoffman M, Troiano J, Li M, Hazelbauer G, Schlau-Cohen G
ACS Chem Biol
. 2021 Oct;
16(11):2472-2480.
PMID: 34647725
Transmembrane receptors are central components of the chemosensory systems by which motile bacteria detect and respond to chemical gradients. An attractant bound to the receptor periplasmic domain generates conformational signals...
5.
Jun S, Pan W, Hazelbauer G
J Bacteriol
. 2020 Apr;
202(13).
PMID: 32341073
In bacterial chemotaxis, chemoreceptors in signaling complexes modulate the activity of two-component histidine kinase CheA in response to chemical stimuli. CheA catalyzes phosphoryl transfer from ATP to a histidinyl residue...
6.
Li M, Hazelbauer G
Protein Sci
. 2019 Oct;
29(2):443-454.
PMID: 31654429
Methylation of specific chemoreceptor glutamyl residues by methyltransferase CheR mediates sensory adaptation and gradient sensing in bacterial chemotaxis. Enzyme action is a function of chemoreceptor signaling conformation: kinase-off receptors are...
7.
Stalla D, Akkaladevi N, White T, Hazelbauer G
Int J Mol Sci
. 2019 Jun;
20(12).
PMID: 31248079
The chemotactic sensory system enables motile bacteria to move toward favorable environments. Throughout bacterial diversity, the chemoreceptors that mediate chemotaxis are clustered into densely packed arrays of signaling complexes. In...
8.
Mello B, Pan W, Hazelbauer G, Tu Y
PLoS Comput Biol
. 2018 Jul;
14(7):e1006305.
PMID: 29965962
It is challenging to decipher molecular mechanisms in biological systems from system-level input-output data, especially for complex processes that involve interactions among multiple components. We addressed this general problem for...
9.
Akkaladevi N, Bunyak F, Stalla D, White T, Hazelbauer G
J Bacteriol
. 2017 Dec;
200(5).
PMID: 29229700
Transmembrane bacterial chemoreceptors are extended, rod-shaped homodimers with ligand-binding sites at one end and interaction sites for signaling complex formation and histidine kinase control at the other. There are atomic-resolution...
10.
Pan W, Dahlquist F, Hazelbauer G
Protein Sci
. 2017 Apr;
26(8):1535-1546.
PMID: 28425142
Autophosphorylating histidine kinase CheA is central to signaling in bacterial chemotaxis. The kinase donates its phosphoryl group to two response regulators, CheY that controls flagellar rotation and thus motility and...