Georgia Zarkada
Overview
Explore the profile of Georgia Zarkada including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1462
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Recent Articles
1.
Zarkada G, Chen X, Zhou X, Lange M, Zeng L, Lv W, et al.
Circ Res
. 2023 Jul;
133(4):333-349.
PMID: 37462027
Background: Lymphatic vessels are responsible for tissue drainage, and their malfunction is associated with chronic diseases. Lymph uptake occurs via specialized open cell-cell junctions between capillary lymphatic endothelial cells (LECs),...
2.
Park S, Ma Z, Zarkada G, Papangeli I, Paluri S, Nazo N, et al.
Pulm Circ
. 2022 Dec;
12(4):e12167.
PMID: 36532314
Modulation of endothelial cell behavior and phenotype by hemodynamic forces involves many signaling components, including cell surface receptors, intracellular signaling intermediaries, transcription factors, and epigenetic elements. Many of the signaling...
3.
Barbacena P, Dominguez-Cejudo M, Fonseca C, Gomez-Gonzalez M, Faure L, Zarkada G, et al.
Dev Cell
. 2022 Oct;
57(19):2321-2333.e9.
PMID: 36220082
Blood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition...
4.
Deng H, Min E, Baeyens N, Coon B, Hu R, Zhuang Z, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(37.
PMID: 34504019
Endothelial cell (EC) sensing of wall fluid shear stress (FSS) from blood flow governs vessel remodeling to maintain FSS at a specific magnitude or set point in healthy vessels. Low...
5.
Li J, Geraldo L, Dubrac A, Zarkada G, Eichmann A
J Am Soc Nephrol
. 2021 Aug;
32(9):2255-2272.
PMID: 34341180
Background: Kidney function requires continuous blood filtration by glomerular capillaries. Disruption of glomerular vascular development or maintenance contributes to the pathogenesis of kidney diseases, but the signaling events regulating renal...
6.
Zarkada G, Howard J, Xiao X, Park H, Bizou M, Leclerc S, et al.
Dev Cell
. 2021 Jul;
56(15):2237-2251.e6.
PMID: 34273276
Endothelial tip cells guiding tissue vascularization are primary targets for angiogenic therapies. Whether tip cells require differential signals to develop their complex branching patterns remained unknown. Here, we show that...
7.
Zhang F, Zarkada G, Yi S, Eichmann A
Front Physiol
. 2020 Jun;
11:509.
PMID: 32547411
Lymphatic endothelial cells (LECs) lining lymphatic vessels develop specialized cell-cell junctions that are crucial for the maintenance of vessel integrity and proper lymphatic vascular functions. Successful lymphatic drainage requires a...
8.
Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, et al.
Science
. 2018 Aug;
361(6402):599-603.
PMID: 30093598
Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-absorbed lipids are packaged into chylomicrons, which enter the bloodstream through intestinal lymphatic vessels called lacteals. Here, we show...
9.
Heinolainen K, Karaman S, DAmico G, Tammela T, Sormunen R, Eklund L, et al.
Circ Res
. 2017 Mar;
120(9):1414-1425.
PMID: 28298294
Rationale: Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals are transduced by VEGFC/D via VEGFR3. VEGFR3...
10.
Nurmi H, Saharinen P, Zarkada G, Zheng W, Robciuc M, Alitalo K
EMBO Mol Med
. 2015 Oct;
7(11):1418-25.
PMID: 26459520
Vascular endothelial growth factor C (VEGF-C) binding to its tyrosine kinase receptor VEGFR-3 drives lymphatic vessel growth during development and in pathological processes. Although the VEGF-C/VEGFR-3 pathway provides a target...