George L Skalka
Overview
Explore the profile of George L Skalka including associated specialties, affiliations and a list of published articles.
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7
Citations
197
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0
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Recent Articles
1.
Muller M, May S, Hall H, Kendall T, McGarry L, Blukacz L, et al.
Nature
. 2025 Feb;
PMID: 39972137
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer-related mortality worldwide. HCC occurs typically from a background of chronic liver disease, caused...
2.
Skalka G, Whyte D, Lubawska D, Murphy D
Essays Biochem
. 2024 Jun;
68(3):295-307.
PMID: 38939918
NUAK1 and NUAK2 belong to a family of kinases related to the catalytic α-subunits of the AMP-activated protein kinase (AMPK) complexes. Despite canonical activation by the tumour suppressor kinase LKB1,...
3.
Skalka G, Tsakovska M, Murphy D
Front Mol Biosci
. 2024 Mar;
11:1354682.
PMID: 38434478
Mitochondria form a critical control nexus which are essential for maintaining correct tissue homeostasis. An increasing number of studies have identified dysregulation of mitochondria as a driver in cancer. However,...
4.
May S, Muller M, Livingstone C, Skalka G, Walsh P, Nixon C, et al.
J Hepatol
. 2023 Jan;
78(5):1028-1036.
PMID: 36702176
Background & Aims: Mouse models of lineage tracing have helped to describe the important subpopulations of hepatocytes responsible for liver regeneration. However, conflicting results have been obtained from different models....
5.
Bader A, Luessing J, Hawley B, Skalka G, Lu W, Lowndes N, et al.
Nucleic Acids Res
. 2022 Oct;
50(18):10487-10502.
PMID: 36200807
Proteins with RNA-binding activity are increasingly being implicated in DNA damage responses (DDR). Additionally, DNA:RNA-hybrids are rapidly generated around DNA double-strand breaks (DSBs), and are essential for effective repair. Here,...
6.
Knight J, Alexandrou C, Skalka G, Vlahov N, Pennel K, Officer L, et al.
Cancer Discov
. 2020 Dec;
11(5):1228-1247.
PMID: 33328217
-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in -mutant colorectal...
7.
Lu W, Hawley B, Skalka G, Baldock R, Smith E, Bader A, et al.
Nat Commun
. 2018 Feb;
9(1):532.
PMID: 29416038
The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of DNA damage but the mechanism remains...
8.
Hollingworth R, Skalka G, Stewart G, Hislop A, Blackbourn D, Grand R
Viruses
. 2015 Jun;
7(6):2908-27.
PMID: 26057167
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of several human malignancies. Human tumour viruses such as KSHV are known to interact with the DNA damage response (DDR), the molecular...