Ann Hedley
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Explore the profile of Ann Hedley including associated specialties, affiliations and a list of published articles.
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53
Citations
2167
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Recent Articles
1.
Muller M, May S, Hall H, Kendall T, McGarry L, Blukacz L, et al.
Nature
. 2025 Feb;
PMID: 39972137
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer-related mortality worldwide. HCC occurs typically from a background of chronic liver disease, caused...
2.
Dalgliesh C, Aldalaqan S, Atallah C, Best A, Scott E, Ehrmann I, et al.
EMBO J
. 2025 Jan;
44(3):877-902.
PMID: 39748121
The cellular concentrations of splicing factors (SFs) are critical for controlling alternative splicing. Most serine and arginine-enriched (SR) protein SFs regulate their own concentration via a homeostatic feedback mechanism that...
3.
Wiesheu R, Edwards S, Hedley A, Hall H, Tosolini M, Fares da Silva M, et al.
EMBO J
. 2024 May;
43(14):2878-2907.
PMID: 38816652
In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host...
4.
Farahmand P, Gyuraszova K, Rooney C, Raffo-Iraolagoitia X, Jayasekera G, Hedley A, et al.
Front Toxicol
. 2023 Jul;
5:1200650.
PMID: 37441092
Asbestos-driven inflammation contributes to malignant pleural mesothelioma beyond the acquisition of rate-limiting mutations. Genetically modified conditional allelic mice that were previously shown to develop mesothelioma in the absence of exposure...
5.
Powell J, Powell S, Mather M, Beck L, Nelson A, Palmowski P, et al.
Thorax
. 2023 Feb;
78(10):1019-1027.
PMID: 36808087
Background: Tracheostomies in children are associated with significant morbidity, poor quality of life, excess healthcare costs and excess mortality. The underlying mechanisms facilitating adverse respiratory outcomes in tracheostomised children are...
6.
Flanagan D, Amirkhah R, Vincent D, Gunduz N, Gentaz P, Cammareri P, et al.
Nat Commun
. 2023 Jan;
14(1):522.
PMID: 36720858
No abstract available.
7.
May S, Muller M, Livingstone C, Skalka G, Walsh P, Nixon C, et al.
J Hepatol
. 2023 Jan;
78(5):1028-1036.
PMID: 36702176
Background & Aims: Mouse models of lineage tracing have helped to describe the important subpopulations of hepatocytes responsible for liver regeneration. However, conflicting results have been obtained from different models....
8.
Edwards S, Hedley A, Hoevenaar W, Wiesheu R, Glauner T, Kilbey A, et al.
J Exp Med
. 2022 Dec;
220(2).
PMID: 36480166
IL-17A-producing γδ T cells in mice consist primarily of Vγ6+ tissue-resident cells and Vγ4+ circulating cells. How these γδ T cell subsets are regulated during homeostasis and cancer remains poorly...
9.
Flanagan D, Amirkhah R, Vincent D, Gunduz N, Gentaz P, Cammareri P, et al.
Nat Commun
. 2022 Dec;
13(1):7551.
PMID: 36477656
The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is controversial. Here, we identify a cohort of born to be bad early-stage (T1) colorectal tumours, with aggressive features...
10.
Freckmann E, Sandilands E, Cumming E, Neilson M, Roman-Fernandez A, Nikolatou K, et al.
Nat Commun
. 2022 Sep;
13(1):5317.
PMID: 36085324
Single cell profiling by genetic, proteomic and imaging methods has expanded the ability to identify programmes regulating distinct cell states. The 3-dimensional (3D) culture of cells or tissue fragments provides...