Martin Bushell
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Explore the profile of Martin Bushell including associated specialties, affiliations and a list of published articles.
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83
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4337
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Recent Articles
1.
Skapik I, Giacomelli C, Hahn S, Deinlein H, Gallant P, Diebold M, et al.
EMBO J
. 2025 Feb;
PMID: 40016419
Protein synthesis is an essential process, deregulated in multiple tumor types showing differential dependence on translation factors compared to untransformed tissue. We show that colorectal cancer (CRC) with loss-of-function mutation...
2.
Dearlove E, Chatrin C, Buetow L, Ahmed S, Schmidt T, Bushell M, et al.
Elife
. 2024 Oct;
13.
PMID: 39377462
Ubiquitination typically involves covalent linking of ubiquitin (Ub) to a lysine residue on a protein substrate. Recently, new facets of this process have emerged, including Ub modification of non-proteinaceous substrates...
3.
Ghashghaei M, Liu Y, Ettles J, Bombaci G, Ramkumar N, Liu Z, et al.
Nat Commun
. 2024 Oct;
15(1):8674.
PMID: 39375334
No abstract available.
4.
Sandovici I, Fernandez-Twinn D, Campbell N, Cooper W, Sekita Y, Zvetkova I, et al.
Cell Rep
. 2024 Sep;
43(9):114750.
PMID: 39283743
Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human diseases, including metabolic disorders and...
5.
Quintas A, Harvey R, Horvilleur E, Garland G, Schmidt T, Kalmar L, et al.
Nucleic Acids Res
. 2024 Sep;
52(19):12039-12054.
PMID: 39225047
RNA binding proteins drive proliferation and tumorigenesis by regulating the translation and stability of specific subsets of messenger RNAs (mRNAs). We have investigated the role of eukaryotic initiation factor 4B...
6.
Ghashghaei M, Liu Y, Ettles J, Bombaci G, Ramkumar N, Liu Z, et al.
Nat Commun
. 2024 Mar;
15(1):2340.
PMID: 38491013
Protein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood. Here, we uncovered CNOT3,...
7.
Pantaleao L, Loche E, Fernandez-Twinn D, Dearden L, Cordova-Casanova A, Osmond C, et al.
Mol Metab
. 2024 Jan;
80:101875.
PMID: 38218535
Objective: We investigated the potential involvement of miRNAs in the developmental programming of cardiovascular diseases (CVD) by maternal obesity. Methods: Serum miRNAs were measured in individuals from the Helsinki Birth...
8.
Bader A, Bushell M
Nat Commun
. 2023 Dec;
14(1):8419.
PMID: 38110444
DNA double-strand breaks (DSBs) are the most mutagenic form of DNA damage, and play a significant role in cancer biology, neurodegeneration and aging. However, studying DSB-induced mutagenesis is limited by...
9.
Screen M, Matheson L, Howden A, Strathdee D, Willis A, Bushell M, et al.
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 38011999
EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions....
10.
Collart M, Audebert L, Bushell M
Wiley Interdiscip Rev RNA
. 2023 Nov;
:e1827.
PMID: 38009591
The Ccr4-Not complex is a global regulator of mRNA metabolism in eukaryotic cells that is most well-known to repress gene expression. Delivery of the complex to mRNAs through a multitude...