George Just
Overview
Explore the profile of George Just including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
121
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Recent Articles
1.
Hayes A, Zheng X, OKelly J, Neyton L, Bochkina N, Uings I, et al.
Cell Rep
. 2023 Jul;
42(8):112763.
PMID: 37478012
Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now. Here, we show...
2.
Verma M, Sooy K, Just G, Nixon M, Morgan R, Andrew R, et al.
Rapid Commun Mass Spectrom
. 2019 Nov;
34 Suppl 4:e8610.
PMID: 31677354
Rationale: The activity of the glucocorticoid activating enzyme 11β-hydroxysteroid dehydrogenase type-1 (11βHSD1) is altered in diseases such as obesity, inflammation and psychiatric disorders. In rodents 11βHSD1 converts inert 11-dehydrocorticosterone (11-DHC)...
3.
Alston R, Connelly M, Mackenzie C, Just G, Homer N
Perfusion
. 2019 Jan;
34(5):392-398.
PMID: 30638148
Background: Administering isoflurane 2.5% into the oxygenator during cardiopulmonary bypass results in no patient movement. However, doing so may result in an excessive depth of anaesthesia particularly, when hypothermia is...
4.
Ng K, Alston R, Just G, McKenzie C
Perfusion
. 2017 Oct;
33(2):148-155.
PMID: 28985693
Introduction: Bispectral index (BIS) and monitoring of end-tidal concentration may be associated with a reduction in the incidence of awareness during volatile-based general anaesthesia. An analogue of end-tidal concentration during...
5.
Stirrat L, Just G, Homer N, Andrew R, Norman J, Reynolds R
Sci Rep
. 2017 Sep;
7(1):10263.
PMID: 28860525
Glucocorticoids are vital for lung maturation. We previously showed that cortisol is lower in obese pregnancy. Whether this is maintained at delivery is unknown but is clinically relevant as maternal...
6.
Ng K, Alston R, Just G, McKenzie C
J Cardiothorac Vasc Anesth
. 2017 May;
31(6):2035-2041.
PMID: 28506542
Objective: Volatile anesthetic agents such as isoflurane may be associated with fewer adverse myocardial events compared with total intravenous anesthesia in cardiac surgery. The authors aimed to determine whether reasonable...
7.
Hamm S, Just G, Lacoste N, Moitessier N, Szyf M, Mamer O
Bioorg Med Chem Lett
. 2007 Dec;
18(3):1046-9.
PMID: 18162397
DNA methylation is an important biological process that programmes gene expression in vertebrates. The methylation pattern is generated by a combination of methylation and demethylation reactions catalyzed by DNA methyltransferases...
8.
Detich N, Hamm S, Just G, Knox J, Szyf M
J Biol Chem
. 2003 Apr;
278(23):20812-20.
PMID: 12676953
S-Adenosylmethionine (AdoMet) is the methyl donor of numerous methylation reactions. The current model is that an increased concentration of AdoMet stimulates DNA methyltransferase reactions, triggering hypermethylation and protecting the genome...
9.
Maier M, Yannopoulos C, Mohamed N, Roland A, Fritz H, Mohan V, et al.
Bioconjug Chem
. 2003 Jan;
14(1):18-29.
PMID: 12526688
Carrier-mediated delivery holds great promise for significantly improving the cellular uptake and therefore the therapeutic efficacy of antisense oligonucleotides in vivo. A multivalent carbohydrate recognition motif for the asialoglycoprotein receptor...
10.
Wang J, Just G
J Org Chem
. 2001 Oct;
64(22):8090-8097.
PMID: 11674721
Several novel chiral indolyl-oxazaphosphorines 7 were synthesized, and their potential as precursors to chiral phosphorothioates was evaluated. Reaction of 7 with a thymidine derivative gave phosphite triester 8 with a...