George-Lucian Moldovan
Overview
Explore the profile of George-Lucian Moldovan including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
4400
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Recent Articles
1.
Dhoonmoon A, Ambrose J, Garg S, Lascarez-Espana C, Rebok A, Spratt T, et al.
Cell Rep
. 2025 Feb;
44(3):115360.
PMID: 40014449
The bypass of DNA lesions by translesion synthesis (TLS) polymerases is a critical step for DNA damage tolerance, allowing the completion of DNA synthesis. It has been under debate whether...
2.
Straka J, Khatib J, Pale L, Nicolae C, Moldovan G
Nucleic Acids Res
. 2024 Nov;
52(22):13865-13880.
PMID: 39558157
Suppression of single-stranded DNA (ssDNA) gap accumulation at replication forks has emerged as a potential determinant of chemosensitivity in homologous recombination (HR)-deficient tumors, as ssDNA gaps are transformed into cytotoxic...
3.
Pale L, Khatib J, Nusawardhana A, Straka J, Nicolae C, Moldovan G
Nucleic Acids Res
. 2024 Nov;
52(22):13832-13848.
PMID: 39530221
Treatment with genotoxic agents, such as platinum compounds, is still the mainstay therapeutical approach for the majority of cancers. Our understanding of the mechanisms of action of these drugs is,...
4.
Hale A, Moldovan G
NAR Cancer
. 2024 Sep;
6(3):zcae038.
PMID: 39319028
Bisphenol A (BPA) is a phenolic chemical that has been used for over 50 years in the manufacturing of polycarbonate and polyvinyl chloride plastics, and it is one of the...
5.
Khatib J, Dhoonmoon A, Moldovan G, Nicolae C
Nat Commun
. 2024 Jul;
15(1):6197.
PMID: 39043663
Replication stress compromises genomic integrity. Fork blocking lesions such as those induced by cisplatin and other chemotherapeutic agents arrest replication forks. Repriming downstream of these lesions represents an important mechanism...
6.
Pale L, Khatib J, Nicolae C, Moldovan G
bioRxiv
. 2024 Apr;
PMID: 38659927
Treatment with genotoxic agents, such as platinum compounds, is still the mainstay therapeutical approach for the majority of cancers. Our understanding of the mechanisms of action of these drugs is...
7.
Nusawardhana A, Pale L, Nicolae C, Moldovan G
Nucleic Acids Res
. 2024 Jan;
52(5):2340-2354.
PMID: 38180818
DNA replication stress-induced fork arrest represents a significant threat to genomic integrity. One major mechanism of replication restart involves repriming downstream of the arrested fork by PRIMPOL, leaving behind a...
8.
Leung W, Baxley R, Traband E, Chang Y, Rogers C, Wang L, et al.
Cell Rep
. 2023 Dec;
42(12):113523.
PMID: 38060446
Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA damage tolerance pathways. Currently, we lack a comprehensive understanding of how PCNA K164 ubiquitination promotes genome stability....
9.
Hale A, Dhoonmoon A, Straka J, Nicolae C, Moldovan G
Nat Commun
. 2023 Oct;
14(1):6265.
PMID: 37805499
Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress, particularly upon inactivation of the BRCA...
10.
Khatib J, Nicolae C, Moldovan G
J Mol Biol
. 2023 Sep;
436(1):168275.
PMID: 37714300
Translesion DNA synthesis (TLS) is a DNA damage tolerance pathway utilized by cells to overcome lesions encountered throughout DNA replication. During replication stress, cancer cells show increased dependency on TLS...