Georg Werner
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Explore the profile of Georg Werner including associated specialties, affiliations and a list of published articles.
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12
Citations
612
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Recent Articles
1.
Reich M, Simon M, Polke B, Paris I, Werner G, Schrader C, et al.
Sci Transl Med
. 2024 Jun;
16(750):eadj7308.
PMID: 38838131
Progranulin (PGRN) haploinsufficiency is a major risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43) pathology (FTLD-). Multiple therapeutic strategies are in clinical development to restore PGRN...
2.
Gnorich J, Reifschneider A, Wind K, Zatcepin A, Kunte S, Beumers P, et al.
J Neuroinflammation
. 2023 Feb;
20(1):47.
PMID: 36829182
Aim: We aimed to investigate the impact of microglial activity and microglial FDG uptake on metabolic connectivity, since microglial activation states determine FDG-PET alterations. Metabolic connectivity refers to a concept...
3.
Krammer C, Yang B, Reichl S, Besson-Girard S, Ji H, Bolini V, et al.
FASEB J
. 2023 Feb;
37(3):e22752.
PMID: 36794636
Atherosclerosis is a chronic inflammatory condition of our arteries and the main underlying pathology of myocardial infarction and stroke. The pathogenesis is age-dependent, but the links between disease progression, age,...
4.
Werner G, Damme M, Schludi M, Gnorich J, Wind K, Fellerer K, et al.
EMBO Rep
. 2020 Sep;
21(10):e50241.
PMID: 32929860
Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) of GRN (progranulin gene) mutation carriers. Currently, it...
5.
Luningschror P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, et al.
Cell Rep
. 2020 Mar;
30(10):3506-3519.e6.
PMID: 32160553
Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging....
6.
Schlepckow K, Monroe K, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, et al.
EMBO Mol Med
. 2020 Mar;
12(4):e11227.
PMID: 32154671
Triggering receptor expressed on myeloid cells 2 (TREM2) is essential for the transition of homeostatic microglia to a disease-associated microglial state. To enhance TREM2 activity, we sought to selectively increase...
7.
Nihei Y, Mori K, Werner G, Arzberger T, Zhou Q, Khosravi B, et al.
Acta Neuropathol
. 2019 Oct;
139(1):99-118.
PMID: 31642962
Repeat expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Expanded sense and antisense repeat RNA transcripts in C9orf72 are translated into five dipeptide-repeat proteins (DPRs) in an...
8.
Gotzl J, Brendel M, Werner G, Parhizkar S, Monasor L, Kleinberger G, et al.
EMBO Mol Med
. 2019 May;
11(6).
PMID: 31122931
Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of variants in genes selectively expressed in microglia are associated...
9.
Gotzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al.
Mol Neurodegener
. 2018 Sep;
13(1):48.
PMID: 30180904
Background: Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to frontotemporal lobar degeneration (FTLD) while the complete loss of progranulin (PGRN) function results in neuronal ceroid lipofuscinosis (NCL), a...
10.
Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, et al.
EMBO Rep
. 2017 May;
18(7):1186-1198.
PMID: 28483841
Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such as Alzheimer's disease and frontotemporal lobar degeneration....