Gernot Kleinberger
Overview
Explore the profile of Gernot Kleinberger including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
4102
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Recent Articles
1.
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, et al.
Nat Neurosci
. 2024 Aug;
27(9):1858-1859.
PMID: 39143410
No abstract available.
2.
Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, et al.
EMBO Rep
. 2024 Jun;
25(7):3161.
PMID: 38849674
No abstract available.
3.
Eninger T, Muller S, Bacioglu M, Schweighauser M, Lambert M, Maia L, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2119804119.
PMID: 35666874
Single-cell transcriptomics has revealed specific glial activation states associated with the pathogenesis of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. While these findings may eventually lead to new therapeutic...
4.
Ali M, Sung Y, Wang F, Fernandez M, Morris J, Fagan A, et al.
PLoS One
. 2022 May;
17(5):e0267298.
PMID: 35617280
Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging,...
5.
Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, et al.
EMBO Rep
. 2022 Apr;
23(6):e53890.
PMID: 35438230
Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and correlates with neurodegeneration in both diseases. In disease, characteristic C-terminal fragments of...
6.
Blume T, Deussing M, Biechele G, Peters F, Zott B, Schmidt C, et al.
Front Aging Neurosci
. 2022 Apr;
14:854031.
PMID: 35431893
We undertook longitudinal β-amyloid positron emission tomography (Aβ-PET) imaging as a translational tool for monitoring of chronic treatment with the peroxisome proliferator-activated receptor gamma (PPARγ) agonist pioglitazone in Aβ model...
7.
Morenas-Rodriguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suarez-Calvet M, et al.
Lancet Neurol
. 2022 Mar;
21(4):329-341.
PMID: 35305339
Background: Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against...
8.
Reifschneider A, Robinson S, van Lengerich B, Gnorich J, Logan T, Heindl S, et al.
EMBO J
. 2022 Jan;
41(4):e109108.
PMID: 35019161
Haploinsufficiency of the progranulin (PGRN)-encoding gene (GRN) causes frontotemporal lobar degeneration (GRN-FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction, and TDP-43 deposition. To understand the contribution of microglial...
9.
Biechele G, Blume T, Deussing M, Zott B, Shi Y, Xiang X, et al.
Theranostics
. 2021 Sep;
11(18):8964-8976.
PMID: 34522221
Modulation of the innate immune system is emerging as a promising therapeutic strategy against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect are ill-understood. Thus, we investigated the...
10.
Franzmeier N, Suarez-Calvet M, Frontzkowski L, Moore A, Hohman T, Morenas-Rodriguez E, et al.
Mol Neurodegener
. 2020 Oct;
15(1):57.
PMID: 33032659
Background: The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a...