Georg Manolikakes
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Explore the profile of Georg Manolikakes including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
1.
Chien P, Breitschaft F, Kelm H, Waldvogel S, Manolikakes G
ChemSusChem
. 2025 Mar;
:e202500186.
PMID: 40066727
A novel, electrochemical 3-component reaction for the synthesis of alkyl alkenesulfonates from cinnamic acids, SO2, and alkyl alcohols is reported. This metal-free process employs inexpensive and readily available graphite electrodes...
2.
Lin C, Huang P, Grassle S, Grathwol C, Tremouilhac P, Vanderheiden S, et al.
Sci Data
. 2025 Jan;
12(1):130.
PMID: 39843501
Results of scientific work in chemistry can usually be obtained in the form of materials and data. A big step towards transparency and reproducibility of the scientific work can be...
3.
Halaczkiewicz M, Maraj A, Riedel M, Donner L, Kelm H, Manolikakes G
Chemistry
. 2024 Dec;
31(10):e202404223.
PMID: 39618076
A highly stereoselective Brønsted-acid catalyzed synthesis of densely substituted spiroisoindolinones from enamides and 3-hydroxy-isoindolinones is described. With simple Brønsted-acids, such as para-toluene sulfonic acid, spiroisoindolinones with three contiguous stereogenic centers...
4.
Roos J, Manolikakes G, Schlomann U, Klinke A, Schopfer F, Neumann C, et al.
Trends Pharmacol Sci
. 2024 Nov;
45(11):1061-1080.
PMID: 39490362
Nitro-fatty acids (NO-FAs) are endogenous pleiotropic lipid mediators regarded as promising drug candidates for treating inflammatory and fibrotic diseases. Over the past two decades, the anti-inflammatory and cytoprotective actions of...
5.
Demuth P, Thibol L, Lemsch A, Potlitz F, Schulig L, Grathwol C, et al.
Cancers (Basel)
. 2024 Oct;
16(20).
PMID: 39456536
The DNA repair protein PARP-1 emerged as a valuable target in the treatment of tumor entities with deficiencies of , such as breast cancer. More recently, the application of PARP...
6.
Olu-Igbiloba O, Sitzmann H, Manolikakes G
J Org Chem
. 2024 May;
89(10):6903-6914.
PMID: 38698761
A three-component synthesis of α-substituted -sulfonyl amines from aryl aldehydes, primary sulfonamides, and (hetero)arenes is described. This transformation enables a straightforward and modular synthesis of highly substituted sulfonamide scaffolds in...
7.
Halaczkiewicz M, Maraj A, Kelm H, Manolikakes G
Org Lett
. 2024 Mar;
26(11):2321-2325.
PMID: 38467018
A highly diastereoselective synthesis of spiroisoindolinones from enamides and 3-hydroxy-isoindolinones is reported. The reaction proceeds rapidly in the presence of -toluenesulfonic acid as a Brønsted acid catalyst and affords a...
8.
Bischoff E, Lang L, Zimmermann J, Luczak M, Kiefer A, Niedner-Schatteburg G, et al.
Free Radic Biol Med
. 2023 Aug;
208:165-177.
PMID: 37541455
Dimedone and its derivates are used as selective probes for the nucleophilic detection of sulfenic acids in biological samples. Qualitative analyses suggested that dimedone also reacts with cyclic sulfenamides. Furthermore,...
9.
Brat C, Huynh Phuoc H, Awad O, Parmar B, Hellmuth N, Heinicke U, et al.
Cell Chem Biol
. 2023 Jul;
30(10):1277-1294.e12.
PMID: 37473760
Nitro-fatty acids (NFAs) are endogenous lipid mediators causing a spectrum of anti-inflammatory effects by covalent modification of key proteins within inflammatory signaling pathways. Recent animal models of solid tumors have...
10.
Jakob B, Schneider N, Gengenbach L, Manolikakes G
Beilstein J Org Chem
. 2023 Jun;
19:719-726.
PMID: 37284589
A palladium-catalyzed enantioselective three-component reaction of glyoxylic acid, sulfonamides and aryltrifluoroborates is described. This process provides modular access to the important α-arylglycine motif in moderate to good yields and enantioselectivies....