Georg Langlhofer
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Explore the profile of Georg Langlhofer including associated specialties, affiliations and a list of published articles.
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11
Citations
102
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Recent Articles
1.
Gupta R, Dittmeier M, Wohlleben G, Nickl V, Bischler T, Luzak V, et al.
Cancer Gene Ther
. 2024 Jul;
31(9):1357-1379.
PMID: 39039193
Trk (NTRK) receptor and NTRK gene fusions are oncogenic drivers of a wide variety of tumors. Although Trk receptors are typically activated at the cell surface, signaling of constitutive active...
2.
Langlhofer G, Kogel A, Schaefer M
Cell Calcium
. 2021 Sep;
99:102469.
PMID: 34509871
Electrical activity and oscillations of cytosolic Ca concentrations ([Ca]) that trigger insulin release in response to glucose are key functions of pancreatic β cells. Although oscillatory Ca signals have been...
3.
Breitinger U, Weinlander K, Pechmann Y, Langlhofer G, Enz R, Becker C, et al.
J Adv Res
. 2021 Apr;
29:95-106.
PMID: 33842008
Introduction: The inhibitory glycine receptor (GlyR), a mediator of fast synaptic inhibition, is located and held at neuronal synapses through the anchoring proteins gephyrin and collybistin. Stable localization of neurotransmitter...
4.
Langlhofer G, Schaefer N, Maric H, Keramidas A, Zhang Y, Baumann P, et al.
J Neurosci
. 2020 May;
40(25):4954-4969.
PMID: 32354853
Glycine receptors (GlyRs) are the major mediators of fast synaptic inhibition in the adult human spinal cord and brainstem. Hereditary mutations to GlyRs can lead to the rare, but potentially...
5.
Langlhofer G, Villmann C
J Neurochem
. 2017 Apr;
142(1):41-55.
PMID: 28429370
Glycine receptor (GlyR) truncations in the intracellular TM3-4 loop, documented in patients suffering from hyperekplexia and in the mouse mutant oscillator, lead to non-functionality of GlyRs. The missing part that...
6.
Langlhofer G, Villmann C
Front Mol Neurosci
. 2016 Jun;
9:41.
PMID: 27330534
The family of Cys-loop receptors (CLRs) shares a high degree of homology and sequence identity. The overall structural elements are highly conserved with a large extracellular domain (ECD) harboring an...
7.
Atak S, Langlhofer G, Schaefer N, Kessler D, Meiselbach H, Delto C, et al.
Front Mol Neurosci
. 2016 Jan;
8:79.
PMID: 26733802
Ligand-binding of Cys-loop receptors is determined by N-terminal extracellular loop structures from the plus as well as from the minus side of two adjacent subunits in the pentameric receptor complex....
8.
Schaefer N, Kluck C, Price K, Meiselbach H, Vornberger N, Schwarzinger S, et al.
J Neurosci
. 2015 Jan;
35(1):422-37.
PMID: 25568133
Recent studies on the pathogenic mechanisms of recessive hyperekplexia indicate disturbances in glycine receptor (GlyR) α1 biogenesis. Here, we examine the properties of a range of novel glycine receptor mutants...
9.
Meiselbach H, Vogel N, Langlhofer G, Stangl S, Schleyer B, Bahnassawy L, et al.
J Biol Chem
. 2014 Aug;
289(42):29135-47.
PMID: 25143388
Cys loop receptors are pentameric arrangements of independent subunits that assemble into functional ion channels. Each subunit shows a domain architecture. Functional ion channels can be reconstituted even from independent,...
10.
Schaefer N, Langlhofer G, Kluck C, Villmann C
Br J Pharmacol
. 2013 Aug;
170(5):933-52.
PMID: 23941355
Human hyperekplexia is a neuromotor disorder caused by disturbances in inhibitory glycine-mediated neurotransmission. Mutations in genes encoding for glycine receptor subunits or associated proteins, such as GLRA1, GLRB, GPHN and...