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Cord-Michael Becker

Explore the profile of Cord-Michael Becker including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 61
Citations 865
Followers 0
Related Specialties
Biochemistry
Neurology
Chemistry
Top 10 Co-Authors
Andreas Humeny
Carmen Villmann
Hans-Georg Breitinger
Kristina Becker
Monika Pischetsrieder
Silke Seeber
Ulrike Breitinger
Angela Seebahn
Wei Xiang
Nico Vogel
Published In
J Biol Chem
J Agric Food Chem
J Neurochem
Clin Chem
J Neurosci
Affiliations
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Recent Articles
1.
A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin
Breitinger U, Weinlander K, Pechmann Y, Langlhofer G, Enz R, Becker C, et al.
J Adv Res . 2021 Apr; 29:95-106. PMID: 33842008
Introduction: The inhibitory glycine receptor (GlyR), a mediator of fast synaptic inhibition, is located and held at neuronal synapses through the anchoring proteins gephyrin and collybistin. Stable localization of neurotransmitter...
2.
PKA and PKC Modulators Affect Ion Channel Function and Internalization of Recombinant Alpha1 and Alpha1-Beta Glycine Receptors
Breitinger U, Bahnassawy L, Janzen D, Roemer V, Becker C, Villmann C, et al.
Front Mol Neurosci . 2018 Jun; 11:154. PMID: 29867346
Glycine receptors (GlyRs) are important mediators of fast inhibitory neurotransmission in the mammalian central nervous system. Their function is controlled by multiple cellular mechanisms, including intracellular regulatory processes. Modulation of...
3.
Loss of glycine receptors containing the α3 subunit compromises auditory nerve activity, but not outer hair cell function
Dlugaiczyk J, Hecker D, Neubert C, Buerbank S, Campanelli D, Becker C, et al.
Hear Res . 2016 May; 337:25-34. PMID: 27208792
Inhibitory glycine receptors containing the α3 subunit (GlyRα3) regulate sensory information processing in the CNS and retina. In previous work, we demonstrated the presence of postsynaptic GlyRα3 immunoreactivity at efferent...
4.
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
Xiang W, Menges S, Schlachetzki J, Meixner H, Hoffmann A, Schlotzer-Schrehardt U, et al.
Mol Neurodegener . 2015 Apr; 10:8. PMID: 25886189
Background: Aggregation and aggregation-mediated formation of toxic alpha synuclein (aSyn) species have been linked to the pathogenesis of sporadic and monogenic Parkinson's disease (PD). A novel H50Q mutation of aSyn,...
5.
Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia
Schaefer N, Kluck C, Price K, Meiselbach H, Vornberger N, Schwarzinger S, et al.
J Neurosci . 2015 Jan; 35(1):422-37. PMID: 25568133
Recent studies on the pathogenic mechanisms of recessive hyperekplexia indicate disturbances in glycine receptor (GlyR) α1 biogenesis. Here, we examine the properties of a range of novel glycine receptor mutants...
6.
Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior
Meiselbach H, Vogel N, Langlhofer G, Stangl S, Schleyer B, Bahnassawy L, et al.
J Biol Chem . 2014 Aug; 289(42):29135-47. PMID: 25143388
Cys loop receptors are pentameric arrangements of independent subunits that assemble into functional ion channels. Each subunit shows a domain architecture. Functional ion channels can be reconstituted even from independent,...
7.
Peptide labeling with photoactivatable trifunctional cadaverine derivative and identification of interacting partners by biotin transfer
App C, Knop J, Huff T, Seebahn A, Becker C, Iavarone F, et al.
Anal Biochem . 2014 Apr; 456:14-21. PMID: 24732115
A new photoactivatable trifunctional cross-linker, cBED (cadaverine-2-[6-(biotinamido)-2-(p-azidobenzamido) hexanoamido]ethyl-1,3'-dithiopropionate), was synthesized by chemical conversion of sulfo-SBED (sulfosuccinimidyl-2-[6-(biotinamido)-2-(p-azidobenzamido) hexanoamido]ethyl-1,3'-dithiopropionate) with cadaverine. This cross-linker was purified by reversed-phase high-performance liquid chromatography (RP-HPLC) and...
8.
Oxidative stress-induced posttranslational modifications of alpha-synuclein: specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity
Xiang W, Schlachetzki J, Helling S, Bussmann J, Berlinghof M, Schaffer T, et al.
Mol Cell Neurosci . 2013 Feb; 54:71-83. PMID: 23369945
Aggregation and neurotoxicity of misfolded alpha-synuclein (αSyn) are crucial mechanisms for progressive dopaminergic neurodegeneration associated with Parkinson's disease (PD). Posttranslational modifications (PTMs) of αSyn caused by oxidative stress, including modification...
9.
Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes
Xiang W, Weisbach V, Sticht H, Seebahn A, Bussmann J, Zimmermann R, et al.
Arch Biochem Biophys . 2012 Dec; 529(1):34-44. PMID: 23201302
Posttranslational modifications (PTMs) have been reported in hemoglobin (Hb) treated with ROS/RNS in cell-free experiments. However, little is known about oxidative PTMs of Hb occurring within the erythrocytes. The aim...
10.
Inhibitory glycine receptors: an update
Dutertre S, Becker C, Betz H
J Biol Chem . 2012 Oct; 287(48):40216-23. PMID: 23038260
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of...