Geoffrey M Wahl
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Explore the profile of Geoffrey M Wahl including associated specialties, affiliations and a list of published articles.
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76
Citations
8292
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Recent Articles
1.
Vallmajo-Martin Q, Ma Z, Srinivasan S, Murali D, Dravis C, Mukund K, et al.
bioRxiv
. 2024 Oct;
PMID: 39415993
The adult mammary gland is maintained by lineage-restricted progenitor cells through pregnancy, lactation, involution, and menopause. Injury resolution, transplantation-associated mammary gland reconstitution, and tumorigenesis are unique exceptions, wherein mammary basal...
2.
Reina J, Vallmajo-Martin Q, Ning J, Michi A, Yeung K, Wahl G, et al.
bioRxiv
. 2024 May;
PMID: 38712081
Triple-negative breast cancer (TNBC) is a highly aggressive and metastatic form of breast cancer that lacks an effective targeted therapy. To identify new therapeutic targets, we investigated the phosphohistidine phosphatase,...
3.
Stanger B, Wahl G
Annu Rev Pathol
. 2023 Oct;
19:397-421.
PMID: 37832945
In the 160 years since Rudolf Virchow first postulated that neoplasia arises by the same law that regulates embryonic development, scientists have come to recognize the striking overlap between the...
4.
Tang R, Shuldiner E, Kelly M, Murray C, Hebert J, Andrejka L, et al.
Nat Cell Biol
. 2023 Jan;
25(1):159-169.
PMID: 36635501
Oncogenic KRAS mutations occur in approximately 30% of lung adenocarcinoma. Despite several decades of effort, oncogenic KRAS-driven lung cancer remains difficult to treat, and our understanding of the regulators of...
5.
Xu Z, Lee D, Chandran S, Le V, Bump R, Yasis J, et al.
Nature
. 2022 Dec;
612(7940):564-572.
PMID: 36477537
Higher-order chromatin structure is important for the regulation of genes by distal regulatory sequences. Structural variants (SVs) that alter three-dimensional (3D) genome organization can lead to enhancer-promoter rewiring and human...
6.
Gubbala V, Jytosana N, Trinh V, Maurer H, Naeem R, Lytle N, et al.
Gastro Hep Adv
. 2022 Oct;
1(4):682-697.
PMID: 36277993
Background And Aims: Eicosanoids, oxidized fatty acids that serve as cell-signaling molecules, have been broadly implicated in tumorigenesis. Here, we aimed to identify eicosanoids associated with pancreatic tumorigenesis and the...
7.
Langille E, Al-Zahrani K, Ma Z, Liang M, Uuskula-Reimand L, Espin R, et al.
Cancer Discov
. 2022 Sep;
12(12):2930-2953.
PMID: 36108220
Significance: Infrequently mutated genes comprise most of the mutational burden in breast tumors but are poorly understood. In vivo CRISPR screening identified functional tumor suppressors that converged on epigenetic regulation....
8.
Ma Z, Lytle N, Ramos C, Naeem R, Wahl G
Methods Mol Biol
. 2022 Feb;
2471:49-82.
PMID: 35175591
Cancers are caricatures of normal development. Yet, for most organs we are only beginning to learn about the molecular events underlying the embryonic antecedents of organogenesis and when differentiation into...
9.
Shi Y, Gao W, Lytle N, Huang P, Yuan X, Dann A, et al.
Nature
. 2021 Dec;
600(7889):E18.
PMID: 34848876
No abstract available.
10.
Ma Z, Lytle N, Chen B, Jyotsana N, Novak S, Cho C, et al.
Gastroenterology
. 2021 Oct;
162(2):604-620.e20.
PMID: 34695382
Background & Aims: Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was...