Geoffrey G Hesketh
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Explore the profile of Geoffrey G Hesketh including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1259
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Recent Articles
21.
Aiba T, Farinelli F, Kostecki G, Hesketh G, Edwards D, Biswas S, et al.
Circ Cardiovasc Genet
. 2014 May;
7(3):249-56.
PMID: 24795344
Background: The mechanisms of the electrocardiographic changes and arrhythmias in Brugada syndrome (BrS) remain controversial. Mutations in the sodium channel gene, SCN5A, and regulatory proteins that reduce or eliminate sodium...
22.
Smyth J, Zhang S, Sanchez J, Lamouille S, Vogan J, Hesketh G, et al.
Traffic
. 2014 Mar;
15(6):684-99.
PMID: 24612377
Altered phosphorylation and trafficking of connexin 43 (Cx43) during acute ischemia contributes to arrhythmogenic gap junction remodeling, yet the critical sequence and accessory proteins necessary for Cx43 internalization remain unresolved....
23.
Aiba T, Barth A, Hesketh G, Hashambhoy Y, Chakir K, Tunin R, et al.
Circ Arrhythm Electrophysiol
. 2013 May;
6(3):546-54.
PMID: 23650309
Background: Slowed Na⁺ current (INa) decay and enhanced late INa (INa-L) prolong the action potential duration (APD) and contribute to early afterdepolarizations. Cardiac resynchronization therapy (CRT) shortens APD compared with...
24.
Schafer I, Hesketh G, Bright N, Gray S, Pryor P, Evans P, et al.
Nat Struct Mol Biol
. 2012 Oct;
19(12):1300-9.
PMID: 23104059
SNAREs provide energy and specificity to membrane fusion events. Fusogenic trans-SNARE complexes are assembled from glutamine-contributing SNAREs (Q-SNAREs) embedded in one membrane and an arginine-contributing SNARE (R-SNARE) embedded in the...
25.
Gebska M, Stevenson B, Hemnes A, Bivalacqua T, Haile A, Hesketh G, et al.
Cardiovasc Res
. 2011 Mar;
90(2):353-63.
PMID: 21421555
Aims: It has been well demonstrated that phosphodiesterase-5A (PDE5A) is expressed in smooth muscle cells and plays an important role in regulation of vascular tone. The role of endothelial PDE5A,...
26.
Hesketh G, Shah M, Halperin V, Cooke C, Akar F, Yen T, et al.
Circ Res
. 2010 Feb;
106(6):1153-63.
PMID: 20167932
Rationale: Gap junctions mediate cell-to-cell electric coupling of cardiomyocytes. The primary gap junction protein in the working myocardium, connexin43 (Cx43), exhibits increased localization at the lateral membranes of cardiomyocytes in...
27.
Koitabashi N, Aiba T, Hesketh G, Rowell J, Zhang M, Takimoto E, et al.
J Mol Cell Cardiol
. 2009 Dec;
48(4):713-24.
PMID: 19961855
Increased cyclic GMP from enhanced synthesis or suppressed catabolism (e.g. PDE5 inhibition by sildenafil, SIL) activates protein kinase G (PKG) and blunts cardiac pathological hypertrophy. Suppressed calcineurin (Cn)-NFAT (nuclear factor...
28.
Aiba T, Hesketh G, Liu T, Carlisle R, Villa-Abrille M, ORourke B, et al.
Cardiovasc Res
. 2009 Oct;
85(3):454-63.
PMID: 19797425
Aims: Calmodulin (CaM) regulates Na+ channel gating through binding to an IQ-like motif in the C-terminus. Ca2+/CaM-dependent protein kinase II (CaMKII) regulates Ca2+ handling, and chronic overactivity of CaMKII is...
29.
Hesketh G, Van Eyk J, Tomaselli G
J Cardiovasc Pharmacol
. 2009 Aug;
54(4):263-72.
PMID: 19701097
Gap junctions (GJs) allow direct communication between cells. In the heart, GJs mediate the electrical coupling of cardiomyocytes and as such dictate the speed and direction of cardiac conduction. A...
30.
Aiba T, Hesketh G, Barth A, Liu T, Daya S, Chakir K, et al.
Circulation
. 2009 Feb;
119(9):1220-30.
PMID: 19237662
Background: Cardiac resynchronization therapy (CRT) is widely applied in patients with heart failure and dyssynchronous contraction (DHF), but the electrophysiological consequences of CRT in heart failure remain largely unexplored. Methods...