Geke Aline Boer
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Explore the profile of Geke Aline Boer including associated specialties, affiliations and a list of published articles.
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8
Citations
86
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Recent Articles
1.
Pretz D, Heyward P, Krebs J, Gruchot J, Barter C, Silcock P, et al.
Life Metab
. 2025 Jan;
2(4):load026.
PMID: 39872248
Butein, a rare chalcone found in the toxic plant , has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta (IKKβ)/nuclear factor kappa...
2.
Boer G, Hay D, Tups A
Trends Pharmacol Sci
. 2022 Dec;
44(1):50-63.
PMID: 36462999
The prevalence of obesity is rising, creating an urgent need for efficacious therapies. Recent clinical trials show that tirzepatide, a dual agonist of receptors for the incretin hormones glucagon-like peptide-1...
3.
Boer G, Hunt J, Gabe M, Windelov J, Sparre-Ulrich A, Hartmann B, et al.
Br J Pharmacol
. 2022 Jun;
179(18):4486-4499.
PMID: 35710141
Background And Purpose: The incretin hormone, gastric inhibitory peptide/glucose-dependent insulinotropic polypeptide (GIP), secreted by the enteroendocrine K-cells in the proximal intestine, may regulate lipid metabolism and adiposity, but its exact...
4.
Gabe M, Skov-Jeppesen K, Gasbjerg L, Schiellerup S, Martinussen C, Gadgaard S, et al.
Pharmacol Res
. 2022 Jan;
176:106058.
PMID: 34995796
The intestinal hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are key regulators of postprandial bone turnover in humans. We hypothesized that GIP and GLP-2 co-administration would provide stronger...
5.
Gadgaard S, van der Velden W, Schiellerup S, Hunt J, Gabe M, Windelov J, et al.
Br J Pharmacol
. 2021 Dec;
179(9):1998-2015.
PMID: 34855984
Background: Glucagon-like peptide-2 (GLP-2) is a pro-glucagon-derived hormone secreted from intestinal enteroendocrine L cells with actions on gut and bones. GLP-2(1-33) is cleaved by DPP-4, forming GLP-2(3-33), having low intrinsic...
6.
Boer G, Keenan S, Miotto P, Holst J, Watt M
Am J Physiol Endocrinol Metab
. 2021 Mar;
320(4):E835-E845.
PMID: 33645252
Glucose-dependent insulinotropic polypeptide (GIP) is best known as an incretin hormone that is secreted from K-cells of the proximal intestine, but evidence also implicates a role for GIP in regulating...
7.
Boer G, Holst J
Biology (Basel)
. 2020 Dec;
9(12).
PMID: 33339298
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from the gut upon nutrient stimulation and regulate postprandial metabolism. These hormones are known as classical incretin hormones and are...
8.
Boer G, Hartmann B, Holst J
Peptides
. 2020 Nov;
136:170457.
PMID: 33245951
Like other peptide hormones, glucose-dependent insulinotropic polypeptide (GIP) is rapidly cleared from the circulation. Dipeptidyl peptidase-4 (DPP-4) is known to be involved. Information on the overall pharmacokinetics of GIP in...
9.
Holst J, Windelov J, Boer G, Pedersen J, Svendsen B, Christensen M, et al.
J Diabetes Investig
. 2016 May;
7 Suppl 1:8-12.
PMID: 27186349
Glucose-dependent insulinotropic polypeptide (GIP) was established as a gut hormone more than 40 years ago, and there is good experimental support for its role as an incretin hormone although deletion...