Gefeng Zhu
Overview
Explore the profile of Gefeng Zhu including associated specialties, affiliations and a list of published articles.
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32
Citations
5881
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Recent Articles
1.
Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, et al.
Science
. 2022 May;
376(6596):996-1001.
PMID: 35617401
T cell quiescence is essential for maintaining a broad repertoire against a large pool of diverse antigens from microbes and tumors, but the underlying molecular mechanisms remain largely unknown. We...
2.
Sun Y, Chen W, Torphy R, Yao S, Zhu G, Lin R, et al.
Sci Transl Med
. 2021 Jul;
13(604).
PMID: 34321321
The immature and dysfunctional vascular network within solid tumors poses a substantial obstacle to immunotherapy because it creates a hypoxic tumor microenvironment that actively limits immune cell infiltration. The molecular...
3.
Wang J, Sanmamed M, Datar I, Tianjiao Su T, Ji L, Sun J, et al.
Cell
. 2018 Dec;
176(1-2):334-347.e12.
PMID: 30580966
Lymphocyte-activation gene 3 (LAG-3) is an immune inhibitory receptor, with major histocompatibility complex class II (MHC-II) as a canonical ligand. However, it remains controversial whether MHC-II is solely responsible for...
4.
Zhu Y, Yao S, Augustine M, Xu H, Wang J, Sun J, et al.
Sci Adv
. 2016 May;
2(4):e1500637.
PMID: 27152329
The central nervous system (CNS) is an immune-privileged organ with the capacity to prevent excessive inflammation. Aside from the blood-brain barrier, active immunosuppressive mechanisms remain largely unknown. We report that...
5.
Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, et al.
PLoS One
. 2015 Jun;
10(6):e0130126.
PMID: 26065426
B7-H3 is a cell surface molecule in the immunoglobulin superfamily that is frequently upregulated in response to autoantigens and pathogens during host T cell immune responses. However, B7-H3's role in...
6.
Zhu Y, Yao S, Iliopoulou B, Han X, Augustine M, Xu H, et al.
Nat Commun
. 2013 Jun;
4:2043.
PMID: 23784006
The B7/CD28 family has profound modulatory effects in immune responses and constitutes an important target for the development of novel therapeutic drugs against human diseases. Here we describe a new...
7.
Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode D, et al.
Immunity
. 2011 May;
34(5):729-40.
PMID: 21530327
CD28 and CTLA-4 are cell surface cosignaling molecules essential for the control of T cell activation upon the engagement of their ligands B7-1 and B7-2 from antigen-presenting cells. By employing...
8.
Narazaki H, Zhu Y, Luo L, Zhu G, Chen L
Blood
. 2010 Jan;
115(10):1941-8.
PMID: 20068221
Antigen-specific memory T cells (Tms) are essential in the immune surveillance of residual and metastatic tumors. Activation of Tms requires designing vaccines based on tumor rejection antigens, which are often...
9.
Omiya R, Tsushima F, Narazaki H, Sakoda Y, Kuramasu A, Kim Y, et al.
Immunology
. 2009 Nov;
128(4):543-55.
PMID: 19930044
Leucocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a membrane receptor of the immunoglobulin (Ig) superfamily that is expressed on most types of haematopoietic cells, and delivers inhibitory signals through interacting with collagens....
10.
Azuma T, Zhu G, Xu H, Rietz A, Drake C, Matteson E, et al.
PLoS Med
. 2009 Oct;
6(10):e1000166.
PMID: 19841745
Background: A pathogenic hallmark of rheumatoid arthritis (RA) is persistent inflammatory responses in target tissues and organs. Immune responses mediated by T cells and autoantibodies are known to play pivotal...