Geeta Ram
Overview
Explore the profile of Geeta Ram including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
505
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0
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Recent Articles
1.
Ram G, Chiu L, Dey S, Ross H, Cammer M, Novick R
Antimicrob Agents Chemother
. 2024 Jul;
68(9):e0023524.
PMID: 39072634
In response to the antimicrobial resistance crisis, we have developed a powerful and versatile therapeutic platform, the Antibacterial Drone (ABD) system. The ABD consists of a highly mobile staphylococcal pathogenicity...
2.
Zhao A, Bodine S, Xie Q, Wang B, Ram G, Novick R, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(33):e2202661119.
PMID: 35939668
In virulence is under the control of a quorum sensing (QS) circuit encoded in the accessory gene regulator () genomic locus. Key to this pathogenic behavior is the production and...
3.
Dhasmana N, Ram G, McAllister K, Chupalova Y, Lopez P, Ross H, et al.
mBio
. 2021 Nov;
12(6):e0208321.
PMID: 34781740
The antibacterial drone (ABD) system is based on repurposing the phage-inducible staphylococcal pathogenicity islands (SaPIs) for use as antibacterial agents that are indifferent to antibiotic resistance. The ABDs were constructed...
4.
Haag A, Podkowik M, Ibarra-Chavez R, Gallego Del Sol F, Ram G, Chen J, et al.
Nat Microbiol
. 2021 Sep;
6(10):1300-1308.
PMID: 34518655
Staphylococcal pathogenicity islands (SaPIs) are a family of closely related mobile chromosomal islands that encode and disseminate the superantigen toxins, toxic shock syndrome toxin 1 and superantigen enterotoxin B (SEB)....
5.
Ram G, Ross H, Novick R, Rodriguez-Pagan I, Jiang D
Nat Biotechnol
. 2018 Sep;
36(10):971-976.
PMID: 30247487
Staphylococcus aureus and other staphylococci continue to cause life-threatening infections in both hospital and community settings. They have become increasingly resistant to antibiotics, especially β-lactams and aminoglycosides, and their infections...
6.
Novick R, Ram G
Curr Opin Microbiol
. 2017 Nov;
38:197-204.
PMID: 29100762
The staphylococcal pathogenicity islands (SaPIs) are highly mobile 15kb genomic islands that carry superantigen genes and other virulence factors and are mobilized by helper phages. Helper phages counteract the SaPI...
7.
Martinez-Rubio R, Quiles-Puchalt N, Marti M, Humphrey S, Ram G, Smyth D, et al.
ISME J
. 2016 Dec;
11(4):1029-1042.
PMID: 27959343
The SaPIs are a cohesive subfamily of extremely common phage-inducible chromosomal islands (PICIs) that reside quiescently at specific att sites in the staphylococcal chromosome and are induced by helper phages...
8.
Novick R, Ram G
Trends Genet
. 2016 Jan;
32(2):114-126.
PMID: 26744223
Among the prokaryotic genomic islands (GIs) involved in horizontal gene transfer (HGT) are the classical pathogenicity islands, including the integrative and conjugative elements (ICEs), the gene-transfer agents (GTAs), and the...
9.
Ram G, Chen J, Ross H, Novick R
Bacteriophage
. 2015 Oct;
5(2):e1028608.
PMID: 26459624
Staphylococcal pathogenicity islands (SaPIs) are ∼15 kb chromosomally located mobile elements that parasitize "helper" phages which provide a de-repressor protein plus virion and lysis proteins which enable the release of...
10.
Chen J, Ram G, Yoong P, Penades J, Shopsin B, Novick R
Plasmid
. 2015 Feb;
79:8-14.
PMID: 25659529
Staphylococcus aureus is one of the most successful bacterial pathogens, harboring a vast repertoire of virulence factors in its arsenal. As such, the genetic manipulation of S. aureus chromosomal DNA...