Gavin Hudson
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Explore the profile of Gavin Hudson including associated specialties, affiliations and a list of published articles.
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97
Citations
3245
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Recent Articles
1.
Hipps D, Pyle A, Porter A, Dobson P, Tuppen H, Lawless C, et al.
Sci Rep
. 2024 Sep;
14(1):20989.
PMID: 39251776
Heteroplasmic mitochondrial DNA (mtDNA) variants accumulate as humans age, particularly in the stem-cell compartments, and are an important contributor to age-related disease. Mitochondrial dysfunction has been observed in osteoporosis and...
2.
Gojanovich G, Marsit C, Kacanek D, Russell J, Hudson G, Van Dyke R, et al.
Mitochondrion
. 2024 Sep;
79:101949.
PMID: 39218053
The prevalence of pathogenic mutations within mitochondrial (mt) DNA of youth who were perinatally exposed to HIV and ART but remained uninfected (YHEU) were assessed relative to phenotypic clinical indicators...
3.
Dobolyi A, Cservenak M, Bago A, Chen C, Stepanova A, Paal K, et al.
Commun Biol
. 2024 Aug;
7(1):1045.
PMID: 39181993
The astrocyte-to-neuron lactate shuttle model entails that, upon glutamatergic neurotransmission, glycolytically derived pyruvate in astrocytes is mainly converted to lactate instead of being entirely catabolized in mitochondria. The mechanism of...
4.
Bury A, Pyle A, Vincent A, Actis P, Hudson G
Sci Rep
. 2024 Jun;
14(1):13789.
PMID: 38877095
Mitochondrial function is critical to continued cellular vitality and is an important contributor to a growing number of human diseases. Mitochondrial dysfunction is typically heterogeneous, mediated through the clonal expansion...
5.
Whittle B, Izuogu O, Lowes H, Deen D, Pyle A, Coxhead J, et al.
NPJ Parkinsons Dis
. 2024 Jan;
10(1):25.
PMID: 38245550
Neurodegeneration in Parkinson's disease (PD) precedes diagnosis by years. Early neurodegeneration may be reflected in RNA levels and measurable as a biomarker. Here, we present the largest quantification of whole...
6.
Takeda Y, Hyslop L, Choudhary M, Robertson F, Pyle A, Wilson I, et al.
EMBO Rep
. 2023 Aug;
24(10):e54540.
PMID: 37589175
Mitochondrial replacement technology (MRT) aims to reduce the risk of serious disease in children born to women who carry pathogenic mitochondrial DNA (mtDNA) variants. By transplanting nuclear genomes from eggs...
7.
Chen C, McDonald D, Blain A, Mossman E, Atkin K, Marusich M, et al.
NPJ Parkinsons Dis
. 2023 Aug;
9(1):120.
PMID: 37553379
Mitochondrial dysfunction has been suggested to contribute to Parkinson's disease pathogenesis, though an understanding of the extent or exact mechanism of this contribution remains elusive. This has been complicated by...
8.
Pickett S, Hudson G, Greaves L
Nat Genet
. 2023 Jun;
55(7):1083-1085.
PMID: 37386252
No abstract available.
9.
Xia C, Pickett S, Liewald D, Weiss A, Hudson G, Hill W
Nat Commun
. 2023 May;
14(1):3146.
PMID: 37253732
Neuroticism is a heritable trait composed of separate facets, each conferring different levels of protection or risk, to health. By examining mitochondrial DNA in 269,506 individuals, we show mitochondrial haplogroups...
10.
Deen D, Alston C, Hudson G, Taylor R, Pyle A
Methods Mol Biol
. 2023 Feb;
2615:397-425.
PMID: 36807806
Pathogenic variants in both mitochondrial and nuclear genes contribute to the clinical and genetic heterogeneity of mitochondrial diseases. There are now pathogenic variants in over 300 nuclear genes linked to...