Gautam Shankar
Overview
Explore the profile of Gautam Shankar including associated specialties, affiliations and a list of published articles.
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23
Citations
587
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Recent Articles
11.
Kanchan K, Grinek S, Bahnson H, Ruczinski I, Shankar G, Larson D, et al.
J Clin Invest
. 2022 Jan;
132(1).
PMID: 34981778
We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted intervention in the LEAP clinical trial. We...
12.
Akenroye A, Brunetti T, Romero K, Daya M, Kanchan K, Shankar G, et al.
J Allergy Clin Immunol
. 2021 Mar;
148(6):1493-1504.
PMID: 33713768
Background: Genetic ancestry plays a role in asthma health disparities. Objective: Our aim was to evaluate the impact of ancestry on and identify genetic variants associated with asthma, total serum...
13.
Bin L, Malley C, Taylor P, Boorgula M, Chavan S, Daya M, et al.
Allergy
. 2021 Feb;
76(8):2510-2523.
PMID: 33548076
Background: Eczema herpeticum (EH) is a rare complication of atopic dermatitis (AD) caused by disseminated herpes simplex virus (HSV) infection. The role of rare and/or deleterious genetic variants in disease...
14.
Yao C, Haensel D, Gaddam S, Patel T, Atwood S, Sarin K, et al.
Nat Commun
. 2020 Oct;
11(1):5079.
PMID: 33033234
Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli signaling, but can develop mechanisms...
15.
Kuonen F, Huskey N, Shankar G, Jaju P, Whitson R, Rieger K, et al.
J Invest Dermatol
. 2019 Feb;
139(7):1439-1448.
PMID: 30707899
Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naive tumor responsiveness to Smoothened inhibitors (Smo), resistance in advanced...
16.
Li L, Wang Y, Torkelson J, Shankar G, Pattison J, Zhen H, et al.
Cell Stem Cell
. 2019 Jan;
24(2):271-284.e8.
PMID: 30686763
Tissue development results from lineage-specific transcription factors (TFs) programming a dynamic chromatin landscape through progressive cell fate transitions. Here, we define epigenomic landscape during epidermal differentiation of human pluripotent stem...
17.
Wan D, Morgan S, Spencley A, Mariano N, Chang E, Shankar G, et al.
Nat Commun
. 2018 Dec;
9(1):5078.
PMID: 30510260
Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its...
18.
Pattison J, Melo S, Piekos S, Torkelson J, Bashkirova E, Mumbach M, et al.
Nat Genet
. 2018 Nov;
50(12):1658-1665.
PMID: 30397335
Human embryonic stem cell (hESC) differentiation promises advances in regenerative medicine, yet conversion of hESCs into transplantable cells or tissues remains poorly understood. Using our keratinocyte differentiation system, we employ...
19.
Morgan S, Chang E, Mariano N, Bermudez A, Arruda N, Wu F, et al.
J Vis Exp
. 2018 Oct;
(139).
PMID: 30272647
Recent studies have clearly shown that long-range, three-dimensional chromatin looping interactions play a significant role in the regulation of gene expression, but whether looping is responsible for or a result...
20.
Whitson R, Lee A, Urman N, Mirza A, Yao C, Brown A, et al.
Nat Med
. 2018 Feb;
24(3):271-281.
PMID: 29400712
Hedgehog pathway-dependent cancers can escape Smoothened (SMO) inhibition through mutations in genes encoding canonical hedgehog pathway components; however, around 50% of drug-resistant basal cell carcinomas (BCCs) lack additional variants of...