Ingo Ruczinski
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Explore the profile of Ingo Ruczinski including associated specialties, affiliations and a list of published articles.
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186
Citations
7753
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Recent Articles
1.
Slack S, Esquinca E, Arehart C, Boorgula M, Szczesny B, Romero A, et al.
medRxiv
. 2025 Feb;
PMID: 39974046
Background: Genetic control of gene expression in asthma-related tissues is not well-characterized, particularly for African-ancestry populations, limiting advancement in our understanding of the increased prevalence and severity of asthma in...
2.
Mangnier L, Ruczinski I, Ricard J, Moreau C, Girard S, Maziade M, et al.
Genet Epidemiol
. 2025 Jan;
49(2):e70001.
PMID: 39876583
A large proportion of genetic variations involved in complex diseases are rare and located within noncoding regions, making the interpretation of underlying biological mechanisms a daunting task. Although technical and...
3.
Wang Z, Grosvenor L, Ray D, Ruczinski I, Beaty T, Volk H, et al.
medRxiv
. 2024 Oct;
PMID: 39417123
Family-based studies provide a unique opportunity to characterize genetic risks of diseases in the presence of population structure, assortative mating, and indirect genetic effects. We propose a novel framework, PGS-TRI,...
4.
Grant-McAuley W, Morgenlander W, Ruczinski I, Kammers K, Laeyendecker O, Hudelson S, et al.
PLoS One
. 2024 Sep;
19(9):e0305976.
PMID: 39288118
Background: High HIV viral loads (VL) are associated with increased morbidity, mortality, and on-going transmission. HIV controllers maintain low VLs in the absence of antiretroviral therapy (ART). We previously used...
5.
Morgenlander W, Chia W, Parra B, Monaco D, Ragan I, Pardo C, et al.
Nat Commun
. 2024 Jul;
15(1):5833.
PMID: 38992033
Arthropod-borne viruses represent a crucial public health threat. Current arboviral serology assays are either labor intensive or incapable of distinguishing closely related viruses, and many zoonotic arboviruses that may transition...
6.
Berke S, Kanchan K, Marazita M, Tobin E, Ruczinski I
medRxiv
. 2024 Jul;
PMID: 38978644
The historically fragmented biomedical data ecosystem has moved towards harmonization under the findable, accessible, interoperable, and reusable (FAIR) data principles, creating more opportunities for cloud-based research. This shift is especially...
7.
Szczesny B, Boorgula M, Chavan S, Campbell M, Johnson R, Kammers K, et al.
Nat Commun
. 2024 May;
15(1):4546.
PMID: 38806494
Asthma has striking disparities across ancestral groups, but the molecular underpinning of these differences is poorly understood and minimally studied. A goal of the Consortium on Asthma among African-ancestry Populations...
8.
Keener R, Chhetri S, Connelly C, Taub M, Conomos M, Weinstock J, et al.
Nat Commun
. 2024 May;
15(1):4417.
PMID: 38789417
Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere...
9.
Liebhoff A, Venkataraman T, Morgenlander W, Na M, Kula T, Waugh K, et al.
Nat Commun
. 2024 Feb;
15(1):1577.
PMID: 38383452
We investigate a relatively underexplored component of the gut-immune axis by profiling the antibody response to gut phages using Phage Immunoprecipitation Sequencing (PhIP-Seq). To cover large antigenic spaces, we develop...
10.
Grant-McAuley W, Morgenlander W, Hudelson S, Thakar M, Piwowar-Manning E, Clarke W, et al.
Front Immunol
. 2023 Sep;
14:1178520.
PMID: 37744365
Background: High HIV viral load (VL) is associated with increased transmission risk and faster disease progression. HIV controllers achieve viral suppression without antiretroviral (ARV) treatment. We evaluated viremic control in...