Gautam Shankar
Overview
Explore the profile of Gautam Shankar including associated specialties, affiliations and a list of published articles.
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23
Citations
587
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Recent Articles
1.
Kinget L, Naulaerts S, Govaerts J, Vanmeerbeek I, Sprooten J, Laureano R, et al.
Nat Med
. 2024 Jul;
30(8):2375-2376.
PMID: 39009782
No abstract available.
2.
Szczesny B, Boorgula M, Chavan S, Campbell M, Johnson R, Kammers K, et al.
Nat Commun
. 2024 May;
15(1):4546.
PMID: 38806494
Asthma has striking disparities across ancestral groups, but the molecular underpinning of these differences is poorly understood and minimally studied. A goal of the Consortium on Asthma among African-ancestry Populations...
3.
Kinget L, Naulaerts S, Govaerts J, Vanmeerbeek I, Sprooten J, Laureano R, et al.
Nat Med
. 2024 May;
30(6):1667-1679.
PMID: 38773341
An important challenge in the real-world management of patients with advanced clear-cell renal cell carcinoma (aRCC) is determining who might benefit from immune checkpoint blockade (ICB). Here we performed a...
4.
De Wispelaere W, Annibali D, Tuyaerts S, Messiaen J, Antoranz A, Shankar G, et al.
Clin Transl Med
. 2024 May;
14(5):e1655.
PMID: 38711203
Background: Uterine leiomyosarcomas (uLMS) are aggressive tumours with poor prognosis and limited treatment options. Although immune checkpoint blockade (ICB) has proven effective in some 'challenging-to-treat' cancers, clinical trials showed that...
5.
Houbaert D, Nikolakopoulos A, Jacobs K, Mece O, Roels J, Shankar G, et al.
Cell Rep
. 2024 Mar;
43(4):114020.
PMID: 38554280
Lymphatic endothelial cells (LECs) of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics. T cell responses to immunotherapy largely rely on peripheral T cell recruitment...
6.
Verhoeven J, Jacobs K, Rizzollo F, Lodi F, Hua Y, Pozniak J, et al.
EMBO Mol Med
. 2023 Nov;
15(12):e18028.
PMID: 38009521
Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune-excluded tumor phenotype. However, the molecular mechanisms that sustain TEC-mediated immunosuppression remain largely elusive. Here, we show that autophagy...
7.
Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma
Finotto L, Cole B, Giese W, Baumann E, Claeys A, Vanmechelen M, et al.
EMBO Mol Med
. 2023 Oct;
15(11):e18144.
PMID: 37791581
Glioblastoma (GBM) remains the most malignant primary brain tumor, with a median survival rarely exceeding 2 years. Tumor heterogeneity and an immunosuppressive microenvironment are key factors contributing to the poor...
8.
Baloh C, Kanchan K, Shankar G, Nepom G, Mathias R, Perry J
J Allergy Clin Immunol
. 2022 Dec;
151(2):416-419.
PMID: 36521801
No abstract available.
9.
Kanchan K, Shankar G, Huffaker M, Bahnson H, Chinthrajah R, Sanda S, et al.
Front Immunol
. 2022 Dec;
13:941839.
PMID: 36466872
Rationale: Previous studies identified an interaction between HLA and oral peanut exposure. HLA-DQA1*01:02 had a protective role with the induction of Ara h 2 epitope-specific IgG4 associated with peanut consumption...
10.
Huffaker M, Kanchan K, Bahnson H, Ruczinski I, Shankar G, Leung D, et al.
J Allergy Clin Immunol
. 2022 Nov;
151(4):1137-1142.e4.
PMID: 36403663
Background: Deleterious variation in the epidermal differentiation complex (EDC) on chromosome 1 is a well-known genetic determinant of atopic dermatitis (AD) and has been associated with risk of peanut allergy...