Gary Gintant
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Explore the profile of Gary Gintant including associated specialties, affiliations and a list of published articles.
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40
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1286
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Recent Articles
1.
Patel M, Peltier H, Matulenko M, Koenig J, Scanio M, Gum R, et al.
Bioorg Med Chem
. 2022 Apr;
63:116743.
PMID: 35436748
The voltage-gated sodium channel Na1.7 is an attractive target for the treatment of pain based on the high level of target validation with genetic evidence linking Na1.7 to pain in...
2.
Valentin J, Hoffmann P, Ortemann-Renon C, Koerner J, Pierson J, Gintant G, et al.
Toxicol Sci
. 2022 Feb;
187(1):3-24.
PMID: 35148401
The content of this article derives from a Health and Environmental Sciences Institute (HESI) consortium with a focus to improve cardiac safety during drug development. A detailed literature review was...
3.
Gintant G
Br J Pharmacol
. 2022 Jan;
179(11):2564-2576.
PMID: 35032025
Advances in non-clinical in vitro models, higher throughput approaches and the promise of human-derived preparations require methods to reliably assess the fidelity of translation of such assays, compared with in...
4.
Pointon A, Maher J, Davis M, Baker T, Cichocki J, Ramsden D, et al.
Lab Chip
. 2021 Jan;
21(3):458-472.
PMID: 33471007
The integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body. Progress has been made in...
5.
Bystricky W, Maier C, Gintant G, Bergau D, Carter D
Front Physiol
. 2020 Oct;
11:567383.
PMID: 33071822
We present continuous T vector velocity (TVV) effect profiles as a new method for identifying drug effects on cardiac ventricular repolarization. TVV measures the temporal change in the myocardial action...
6.
Gintant G, Kaushik E, Feaster T, Stoelzle-Feix S, Kanda Y, Osada T, et al.
Regul Toxicol Pharmacol
. 2020 Aug;
117:104756.
PMID: 32822771
Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on human ventricular repolarization. Two recent large validation studies...
7.
Kramer J, Himmel H, Lindqvist A, Stoelzle-Feix S, Chaudhary K, Li D, et al.
Sci Rep
. 2020 Jul;
10(1):11884.
PMID: 32665705
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Kramer J, Himmel H, Lindqvist A, Stoelzle-Feix S, Chaudhary K, Li D, et al.
Sci Rep
. 2020 Mar;
10(1):5627.
PMID: 32221320
Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures...
9.
Gintant G, Traebert M
Expert Opin Drug Discov
. 2020 Mar;
15(6):719-729.
PMID: 32129680
Introduction: Human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) preparations are increasingly employed in cardiac safety studies to support candidate drug selection and regulatory submissions. The value of hiPSC-CM-based approaches depends...
10.
Seltzer J, Gintant G, Amiri-Kordestani L, Singer J, Koplowitz L, Moslehi J, et al.
Am Heart J
. 2019 Dec;
218:133.
PMID: 31806089
No abstract available.