Khuram W Chaudhary
Overview
Explore the profile of Khuram W Chaudhary including associated specialties, affiliations and a list of published articles.
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20
Citations
444
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Recent Articles
1.
Chaudhary K, Clancy C, Yang P, Pierson J, Goldin A, Koerner J, et al.
Clin Transl Sci
. 2024 Dec;
17(12):e70098.
PMID: 39660576
The human voltage-gated sodium channel Na1.5 (hNa1.5/SCN5A) plays a critical role in the initiation and propagation of action potentials in cardiac myocytes, and its modulation by various drugs has significant...
2.
Pero J, Mueller E, Adams A, Adolph R, Bagchi P, Balce D, et al.
J Med Chem
. 2024 Aug;
67(16):14586-14608.
PMID: 39136957
In the aftermath of the COVID-19 pandemic, opportunities to modulate biological pathways common to the lifecycles of viruses need to be carefully considered. -linked glycosylation in humans is mediated exclusively...
3.
Stebbeds W, Raniga K, Standing D, Wallace I, Bayliss J, Brown A, et al.
Toxicol Sci
. 2023 Jul;
195(1):61-70.
PMID: 37462734
Cardiovascular toxicity is an important cause of drug failures in the later stages of drug development, early clinical safety assessment, and even postmarket withdrawals. Early-stage in vitro assessment of potential...
4.
Ingleby-Talecki L, van Dijkman S, Oosterholt S, Della Pasqua O, Winter C, Cunnington M, et al.
Clin Transl Sci
. 2022 May;
15(8):1978-1989.
PMID: 35579204
Lamotrigine, approved for use as an antiseizure medication as well as the treatment of bipolar disorder, inhibits sodium channels in the brain to reduce repetitive neuronal firing and pathological release...
5.
Delaunois A, Abernathy M, Anderson W, Beattie K, Chaudhary K, Coulot J, et al.
Clin Transl Sci
. 2021 Feb;
14(3):1133-1146.
PMID: 33620150
We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of chloroquine (CLQ) or hydroxychloroquine...
6.
Vargas H, Rolf M, Wisialowski T, Achanzar W, Bahinski A, Bass A, et al.
Clin Pharmacol Ther
. 2020 Sep;
109(2):310-318.
PMID: 32866317
Defining an appropriate and efficient assessment of drug-induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide....
7.
Kramer J, Himmel H, Lindqvist A, Stoelzle-Feix S, Chaudhary K, Li D, et al.
Sci Rep
. 2020 Jul;
10(1):11884.
PMID: 32665705
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Haile P, Casillas L, Bury M, Mehlmann J, Singhaus Jr R, Charnley A, et al.
ACS Med Chem Lett
. 2020 Jun;
11(6):1353.
PMID: 32551024
[This corrects the article DOI: 10.1021/acsmedchemlett.8b00344.].
9.
Kramer J, Himmel H, Lindqvist A, Stoelzle-Feix S, Chaudhary K, Li D, et al.
Sci Rep
. 2020 Mar;
10(1):5627.
PMID: 32221320
Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures...
10.
Ribeiro A, Guth B, Engwall M, Eldridge S, Foley C, Guo L, et al.
Front Pharmacol
. 2019 Sep;
10:934.
PMID: 31555128
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the...