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Garry R Smith

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Articles 25
Citations 270
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Recent Articles
1.
Messick T, Tolvinski L, Zartler E, Moberg A, Frostell A, Smith G, et al.
Molecules . 2020 Apr; 25(7). PMID: 32290261
The human gamma-herpesviruses Epstein-Barr virus (EBV) (HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV) (HHV-8) are responsible for a number of diseases, including various types of cancer. Epstein-Barr nuclear antigen 1 (EBNA1)...
2.
Messick T, Smith G, Soldan S, McDonnell M, Deakyne J, Malecka K, et al.
Sci Transl Med . 2019 Mar; 11(482). PMID: 30842315
Epstein-Barr virus (EBV) is a DNA tumor virus responsible for 1 to 2% of human cancers including subtypes of Burkitt's lymphoma, Hodgkin's lymphoma, gastric carcinoma, and nasopharyngeal carcinoma (NPC). Persistent...
3.
Pelletier J, Chen S, Bian H, Shah R, Smith G, Wrobel J, et al.
ACS Med Chem Lett . 2018 Jul; 9(7):752-756. PMID: 30034613
We have previously reported a prodrug strategy based on the marketed drug riluzole (2-amino-6-trifluoromethoxybenzothiazole), associated with the benefits of lower patient to patient variability of exposure and potentially once daily...
4.
Hicks C, Huang P, Ramos L, Nayak S, Caro Y, Reitz A, et al.
ACS Chem Neurosci . 2018 Mar; 9(6):1327-1337. PMID: 29597343
Psychostimulant reinforcement is mediated by stimulation of both dopamine (DA) D1-like and D2-like receptors, suggesting that pharmacotherapy agents with a dual DA receptor mechanism may be useful for managing psychostimulant...
5.
Oliver C, Simmons S, Nayak S, Smith G, Reitz A, Rawls S
Drug Alcohol Depend . 2018 Mar; 186:75-79. PMID: 29550625
Background And Purpose: Little is known about how chemokine systems influence the behavioral effects of designer cathinones and psychostimulants. The chemokine CXCL12 and its principal receptor target, CXCR4, are of...
6.
Hicks C, Gregg R, Nayak S, Cannella L, Schena G, Tallarida C, et al.
Psychopharmacology (Berl) . 2017 Mar; 234(11):1671-1681. PMID: 28251297
Rationale: Metabotropic glutamate 2 and 3 (mGluR2/3) receptors are implicated in drug addiction as they limit excessive glutamate release during relapse. N-acetylaspartylglutamate (NAAG) is an endogenous mGluR2/3 agonist that is...
7.
Bompiani K, Caglic D, Krutein M, Benoni G, Hrones M, Lairson L, et al.
ACS Comb Sci . 2016 Jun; 18(8):461-74. PMID: 27314875
Botulism is caused by potent and specific bacterial neurotoxins that infect host neurons and block neurotransmitter release. Treatment for botulism is limited to administration of an antitoxin within a short...
8.
Gregg R, Hicks C, Nayak S, Tallarida C, Nucero P, Smith G, et al.
Neuropharmacology . 2016 Apr; 108:111-9. PMID: 27085607
Synthetic cathinones produce dysregulation of monoamine systems, but their effects on the glutamate system and the influence of glutamate on behavioral effects related to cathinone abuse are unknown. A principal...
9.
Briegel A, Cummings A, Smith G, Doroski M, Boyko W, Piro N, et al.
Carbohydr Res . 2015 May; 409:63-8. PMID: 25957213
Lemonose is a component of the antibiotic lemonomycin and other antibiotics and natural products. Three routes to the synthesis of the title compound, a protected, desmethyl derivative of lemonose, from...
10.
Martin M, Calcul L, Smith C, Jinwal U, Fontaine S, Darling A, et al.
ACS Chem Biol . 2015 Jan; 10(4):1099-109. PMID: 25588114
We previously discovered that one specific scalemic preparation of myricanol (1), a constituent of Myrica cerifera (bayberry/southern wax myrtle) root bark, could lower the levels of the microtubule-associated protein tau...