Ganga Reddy Velma
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Explore the profile of Ganga Reddy Velma including associated specialties, affiliations and a list of published articles.
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9
Citations
17
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Recent Articles
1.
Reddy T, Priver S, Ojha R, Mirzadeh N, Velma G, Jakku R, et al.
Eur J Med Chem
. 2024 Nov;
281:117007.
PMID: 39500067
Four new mononuclear gold (I) compounds of the type [AuL{κC-2-CHP(S)Ph}] {L = PTA (1), PPh (2), PPh(CH-3-SONa) (3), and PPh(2-py) (4)} were prepared by scission of the dinuclear compound [Au{μ-2-CHP(S)Ph}]...
2.
Velma G, Laham M, Lewandowski C, Valencia-Olvera A, Balu D, Moore A, et al.
J Med Chem
. 2024 Aug;
67(17):15061-15079.
PMID: 39191400
Therapeutics enhancing apolipoprotein (APOE) positive function are a priority, because is the major genetic risk factor for Alzheimer's disease (AD). The function of APOE, the key constituent of lipoprotein particles...
3.
Velma G, Shen Z, Holberg C, Fu J, Soleymani F, Cooper L, et al.
J Med Chem
. 2024 Aug;
67(16):13681-13702.
PMID: 39102360
The SARS-CoV-2 papain-like protease (PLpro), essential for viral processing and immune response disruption, is a promising target for treating acute infection of SARS-CoV-2. To date, there have been no reports...
4.
Velma G, Krider I, Alves E, Courey J, Laham M, Thatcher G
J Med Chem
. 2024 Apr;
67(8):5999-6026.
PMID: 38580317
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD biosynthesis via salvage of NAM formed from catabolism of NAD by proteins with NADase activity (e.g., PARPs, SIRTs, CD38). Depletion of...
5.
Gordon-Blake J, Ratia K, Weidig V, Velma G, Ackerman-Berrier M, Penton C, et al.
ACS Med Chem Lett
. 2024 Feb;
15(2):205-214.
PMID: 38352833
Evidence supports boosting nicotinamide adenine dinucleotide (NAD) to counteract oxidative stress in aging and neurodegenerative disease. One approach is to enhance the activity of nicotinamide phosphoribosyltransferase (NAMPT). Novel NAMPT positive...
6.
Shen Z, Ratia K, Krider I, Ackerman-Berrier M, Penton C, Musku S, et al.
J Med Chem
. 2023 Dec;
66(24):16704-16727.
PMID: 38096366
Depletion of nicotinamide adenine dinucleotide (NAD) is associated with aging and disease, spurring the study of dietary supplements to replenish NAD. The catabolism of NAD to nicotinamide (NAM) requires the...
7.
Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD
Ratia K, Shen Z, Gordon-Blake J, Lee H, Laham M, Krider I, et al.
Biochemistry
. 2023 Feb;
62(4):923-933.
PMID: 36746631
In aging and disease, cellular nicotinamide adenine dinucleotide (NAD) is depleted by catabolism to nicotinamide (NAM). NAD supplementation is being pursued to enhance human healthspan and lifespan. Activation of nicotinamide...
8.
Mirzadeh N, Telukutla S, Luwor R, Priver S, Velma G, Jakku R, et al.
Metallomics
. 2021 Jun;
13(7).
PMID: 34165566
Increasingly explored over the last decade, gold complexes have shown great promise in the field of cancer therapeutics. A major obstacle to their clinical progression has been their lack of...
9.
Ragi N, Velma G, Pallerla P, Siddiqua S, Alugonda V, Rachamalla H, et al.
J Pharm Biomed Anal
. 2020 Jul;
188:113442.
PMID: 32622114
Vortioxetine (VTX) is a novel multimodal antidepressant drug that affects the serotoninergic and noradrenergic systems. In this work, the forced degradation of VTX was studied according to (ICH) Q1A (R2)...