Christopher Penton
Overview
Explore the profile of Christopher Penton including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
61
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0
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Recent Articles
1.
Velma G, Laham M, Lewandowski C, Valencia-Olvera A, Balu D, Moore A, et al.
J Med Chem
. 2024 Aug;
67(17):15061-15079.
PMID: 39191400
Therapeutics enhancing apolipoprotein (APOE) positive function are a priority, because is the major genetic risk factor for Alzheimer's disease (AD). The function of APOE, the key constituent of lipoprotein particles...
2.
Gordon-Blake J, Ratia K, Weidig V, Velma G, Ackerman-Berrier M, Penton C, et al.
ACS Med Chem Lett
. 2024 Feb;
15(2):205-214.
PMID: 38352833
Evidence supports boosting nicotinamide adenine dinucleotide (NAD) to counteract oxidative stress in aging and neurodegenerative disease. One approach is to enhance the activity of nicotinamide phosphoribosyltransferase (NAMPT). Novel NAMPT positive...
3.
Shen Z, Ratia K, Krider I, Ackerman-Berrier M, Penton C, Musku S, et al.
J Med Chem
. 2023 Dec;
66(24):16704-16727.
PMID: 38096366
Depletion of nicotinamide adenine dinucleotide (NAD) is associated with aging and disease, spurring the study of dietary supplements to replenish NAD. The catabolism of NAD to nicotinamide (NAM) requires the...
4.
Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD
Ratia K, Shen Z, Gordon-Blake J, Lee H, Laham M, Krider I, et al.
Biochemistry
. 2023 Feb;
62(4):923-933.
PMID: 36746631
In aging and disease, cellular nicotinamide adenine dinucleotide (NAD) is depleted by catabolism to nicotinamide (NAM). NAD supplementation is being pursued to enhance human healthspan and lifespan. Activation of nicotinamide...
5.
Hagbard L, Cameron K, August P, Penton C, Parmar M, Hay D, et al.
Philos Trans R Soc Lond B Biol Sci
. 2018 May;
373(1750).
PMID: 29786564
Over the past few decades, a variety of different reagents for stem cell maintenance and differentiation have been commercialized. These reagents share a common goal in facilitating the manufacture of...
6.
Afelik S, Pool B, Schmerr M, Penton C, Jensen J
Dev Biol
. 2015 Jan;
399(2):204-17.
PMID: 25576928
Wnt signaling is a well conserved pathway critical for growth, patterning and differentiation of multiple tissues and organs. Previous studies on Wnt signaling in the pancreas have been based predominantly...